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Correspondence
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Volume 343:361-363 August 3, 2000 Number 5
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The Ethics of Research in Developing Countries

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 by Angell, M.
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 by Brennan, T. A.
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To the Editor: The editorial by Dr. Angell (March 30 issue)1 that accompanied our article2 conflated two Rakai Project studies. We conducted a community-based, randomized trial of sexually transmitted disease (STD) control for the prevention of human immunodeficiency virus (HIV) infection in the Rakai district of Uganda,3 involving 15,127 persons. We subsequently performed a secondary analysis of HIV viral load in 415 retrospectively identified couples in which one partner was HIV-positive and one was initially HIV-negative.2

In her editorial, Dr. Angell suggests that the HIV-positive study participants could have easily been treated with antiretroviral drugs. This is incorrect. The STD . . . [Full Text of this Article]

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