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Previous Volume 343:481-492 August 17, 2000 Number 7 Next

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The Epstein–Barr virus (EBV) was discovered 36 years ago by electron microscopy of cells cultured from Burkitt's lymphoma tissue by Epstein, Achong, and Barr.¹ Four years later, in 1968, EBV was shown to be the etiologic agent of heterophile-positive infectious mononucleosis.² EBV DNA was detected in tissues from patients with nasopharyngeal carcinoma in 1970.³ In the 1980s, EBV was found to be associated with non-Hodgkin's lymphoma and oral hairy leukoplakia in patients with the acquired immunodeficiency syndrome (AIDS).^4,5 Since then, EBV DNA has been found in tissues from other cancers, including T-cell lymphomas and Hodgkin's disease.^6,7

EBV is one of . . . [Full Text of this Article]

Virologic Features

Replication

Latent Infection

Immune Response to EBV and Evasion of the Immune System by the Virus

Clinical Syndromes

Infectious Mononucleosis

Chronic Active EBV Infection

X-Linked Lymphoproliferative Disease

Cancers Associated with EBV

Nasopharyngeal Carcinoma

Burkitt's Lymphoma

Hodgkin's Disease

Lymphoproliferative Disease

Other Cancers

EBV and HIV

Oral Hairy Leukoplakia

Lymphoid Interstitial Pneumonitis

Non-Hodgkin's Lymphoma

Treatment

Infectious Mononucleosis

EBV Lymphoproliferative Disease

Prevention and Vaccines

Source Information

From the Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Md.

Address reprint requests to Dr. Cohen at the Laboratory of Clinical Investigation, National Institutes of Health, Bldg. 10, Rm. 11N214, 10 Center Dr., Bethesda, MD 20892-1888, or at jcohen@niaid.nih.gov.

References

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