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Previous Volume 343:502-503 August 17, 2000 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Alzheimer's disease is a chronic disorder with a gradual onset and slowly progressive course that is characterized by an inevitable deterioration in cognitive function. To develop new methods to prevent and treat Alzheimer's disease, we must be able to diagnose the preclinical stage of the disease, before the brain damage becomes irreversible. The presymptomatic phase of Alzheimer's disease has therefore been the focus of intense research.

The brains of patients with Alzheimer's disease show extensive neuronal loss, the accumulation of ß-amyloid, and extracellular senile plaques and intracellular neurofibrillary tangles in the hippocampus and frontal and temporal cortexes. Minor pathological changes . . . [Full Text of this Article]

References

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• Bunce, D., Kivipelto, M., Wahlin, A. (2005). Apolipoprotein E, B Vitamins, and Cognitive Function in Older Adults. J. Gerontol. B Psychol. Sci. Soc. Sci. 60: P41-P48 [Abstract] [Full Text]  
• Tian, J, Bucks, R S, Haworth, J, Wilcock, G (2003). Neuropsychological prediction of conversion to dementia from questionable dementia: statistically significant but not yet clinically useful. J. Neurol. Neurosurg. Psychiatry 74: 433-438 [Abstract] [Full Text]