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Correspondence
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Volume 343:511-512 August 17, 2000 Number 7
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Chest Pain and Normal Coronary Arteries

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 by Buchthal, S. D.
To the Editor: Buchthal et al. (March 23 issue)1 report an abnormal, reversible decrease in the myocardial phosphocreatine:ATP ratio during mild handgrip exercise, a finding suggestive of ischemia, in 7 of 35 women with angina and no angiographically significant coronary stenoses and in 4 of 11 patients with critical stenoses. This observation was made possible by the application of myocardial phosphorus-31 nuclear magnetic resonance spectroscopy, which appears to have sufficient sensitivity to detect metabolic ischemic alterations in the anterior cardiac wall in the absence of ischemic ST-segment changes. However, the finding of a positive response in only 20 percent of . . . [Full Text of this Article]

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