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Previous Volume 344:11-16 January 4, 2001 Number 1 Next

	Full Text PDF Editorial by Archer, G. L. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background The consequences of infection with Staphylococcus aureus can be severe, so strategies for prevention are important. We examined S. aureus isolates from blood and from nasal specimens to determine whether the organisms in the bloodstream originated from the patient's own flora.

Methods In a multicenter study, swabs for culture were obtained from the anterior nares of 219 patients with S. aureus bacteremia. A total of 723 isolates were collected and genotyped. In a second study, 1640 S. aureus isolates from nasal swabs from 1278 patients were collected over a period of five years and then compared with isolates from the blood of patients who subsequently had S. aureus bacteremia.

Results In the multicenter study of S. aureus bacteremia, the blood isolates were identical to those from the anterior nares in 180 of 219 patients (82.2 percent). In the second study, 14 of 1278 patients who had nasal colonization with S. aureus subsequently had S. aureus bacteremia. In 12 of these 14 patients (86 percent), the isolates obtained from the nares were clonally identical to the isolates obtained from blood 1 day to 14 months later.

Conclusions A substantial proportion of cases of S. aureus bacteremia appear to be of endogenous origin since they originate from colonies in the nasal mucosa. These results provide support for strategies to prevent systemic S. aureus infections by eliminating nasal carriage of S. aureus.

Source Information

From the Institute of Medical Microbiology, University of Münster, Münster (C.E., K.B., G.P.); and SmithKline Beecham, Munich (K.M., H.S.) — both in Germany.

Address reprint requests to Dr. von Eiff at the Institute of Medical Microbiology, Westf älische Wilhems-Universität Münster, Domagkstr. 10, 48149 Münster, Germany, or at eiffc{at}uni-muenster.de.

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• Nouwen, J., Boelens, H., van Belkum, A., Verbrugh, H. (2004). Human Factor in Staphylococcus aureus Nasal Carriage. Infect. Immun. 72: 6685-6688 [Abstract] [Full Text]  
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• Saiman, L., Siegel, J. (2004). Infection Control in Cystic Fibrosis. Clin. Microbiol. Rev. 17: 57-71 [Abstract] [Full Text]  
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• Khatib, R., Sharma, M., Naqvi, S. A. H., Riederer, K., Almoujahed, M. O., Fakih, M. G. (2003). Molecular Analysis of Staphylococcus aureus Blood Isolates Shows Lack of Polyclonal Bacteremia. J. Clin. Microbiol. 41: 1717-1719 [Abstract] [Full Text]  
• Gluck, U., Gebbers, J.-O. (2003). Ingested probiotics reduce nasal colonization with pathogenic bacteria (Staphylococcus aureus, Streptococcus pneumoniae, and {beta}-hemolytic streptococci). Am. J. Clin. Nutr. 77: 517-520 [Abstract] [Full Text]  
• Jones, C. (2003). An Infant in Septic Shock. CLIN PEDIATR 42: 85-87  
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• von Eiff, C., Kipp, F., Becker, K., Delgado-Hachmeister, J. E., Graviss, E. A., Perl, T. M., Zimmerman, M. B. (2002). Intranasal Mupirocin to Prevent Postoperative Infections. NEJM 347: 1207-1208 [Full Text]  
• Peacock, S. J., de Silva, G. D. I., Justice, A., Cowland, A., Moore, C. E., Winearls, C. G., Day, N. P. J. (2002). Comparison of Multilocus Sequence Typing and Pulsed-Field Gel Electrophoresis as Tools for Typing Staphylococcus aureus Isolates in a Microepidemiological Setting. J. Clin. Microbiol. 40: 3764-3770 [Abstract] [Full Text]  
• Cespedes, C., Miller, M., Quagliarello, B., Vavagiakis, P., Klein, R. S., Lowy, F. D. (2002). Differences between Staphylococcus aureus Isolates from Medical and Nonmedical Hospital Personnel. J. Clin. Microbiol. 40: 2594-2597 [Abstract] [Full Text]  
• Perl, T. M., Cullen, J. J., Wenzel, R. P., Zimmerman, M. B., Pfaller, M. A., Sheppard, D., Twombley, J., French, P. P., Herwaldt, L. A., the Mupirocin and the Risk of Staphylococcus aureu, (2002). Intranasal Mupirocin to Prevent Postoperative Staphylococcus aureus Infections. NEJM 346: 1871-1877 [Abstract] [Full Text]  
• Hussain, M., Haggar, A., Heilmann, C., Peters, G., Flock, J.-I., Herrmann, M. (2002). Insertional Inactivation of eap in Staphylococcus aureus Strain Newman Confers Reduced Staphylococcal Binding to Fibroblasts. Infect. Immun. 70: 2933-2940 [Abstract] [Full Text]  
• Chastre, J., Fagon, J.-Y. (2002). Ventilator-associated Pneumonia. Am. J. Respir. Crit. Care Med. 165: 867-903 [Abstract] [Full Text]  
• von Eiff, C., Peters, G. (2002). Comparative in vitro activity of ABT-773 and two macrolides against staphylococci. J Antimicrob Chemother 49: 189-192 [Abstract] [Full Text]  
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• Hussain, M., Becker, K., von Eiff, C., Schrenzel, J., Peters, G., Herrmann, M. (2001). Identification and Characterization of a Novel 38.5-Kilodalton Cell Surface Protein of Staphylococcus aureus with Extended-Spectrum Binding Activity for Extracellular Matrix and Plasma Proteins. J. Bacteriol. 183: 6778-6786 [Abstract] [Full Text]  
• Osmon, D. R. (2001). Antimicrobial Resistance: Guidelines for the Practicing Orthopaedic Surgeon. JBJS 83: 1891-1901 [Full Text]  
• Cole, A. M., Tahk, S., Oren, A., Yoshioka, D., Kim, Y.-H., Park, A., Ganz, T. (2001). Determinants of Staphylococcusaureus Nasal Carriage. CVI 8: 1064-1069 [Abstract] [Full Text]  
• Hussain, M., Becker, K., von Eiff, C., Peters, G., Herrmann, M. (2001). Analogs of Eap Protein Are Conserved and Prevalent in Clinical Staphylococcus aureus Isolates. CVI 8: 1271-1276 [Abstract] [Full Text]  
• van Belkum, A., Verbrugh, H. (2001). 40 years of methicillin resistant Staphylococcus aureus. BMJ 323: 644-645 [Full Text]  
• Gluck, U., Lecomte, F., Nouvellon, M., Levesque, H., Johnson, J. R., Harbarth, S., Gundlapalli, A. V., Samore, M. H., von Eiff, C., Becker, K., Peters, G. (2001). Nasal Carriage of Staphylococcus aureus. NEJM 344: 1399-1401 [Full Text]  
• (2001). The Nose Knows: The Anterior Nares as the Source of Staphylococcus aureus Bacteremia. JWatch Emergency Med. 2001: 4-4 [Full Text]  
• (2001). Staph Moves from Nose to Blood. JWatch General 2001: 3-3 [Full Text]  
• (2001). Where Does Staph Come From? The Nose Knows!. JWatch Infect. Diseases 2001: 13-13 [Full Text]  
• Archer, G. L., Climo, M. W. (2001). Staphylococcus aureus Bacteremia -- Consider the Source. NEJM 344: 55-56 [Full Text]  
• Nelson, D., Loomis, L., Fischetti, V. A. (2001). Prevention and elimination of upper respiratory colonization of mice by group A streptococci by using a bacteriophage lytic enzyme. Proc. Natl. Acad. Sci. USA 98: 4107-4112 [Abstract] [Full Text]