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Previous Volume 344:68 January 4, 2001 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Bone marrow transplantation can eliminate sickle cell disease and halt end-organ damage.^1,2 However, the applicability of the procedure is limited because of the toxic effects associated with conventional bone marrow transplantation. Nonmyeloablative conditioning regimens can decrease or eliminate such toxic effects.^3,4,5

An eight-year-old girl with homozygous sickle cell disease had been receiving monthly transfusions and chelation therapy with deferoxamine since having a stroke three years earlier. Before the stroke, she had required three or four hospitalizations per year for vaso-occlusive crises and the acute chest syndrome. We treated the girl with a bone marrow transplant from her . . . [Full Text of this Article]

References

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• Kean, L. S., Durham, M. M., Adams, A. B., Hsu, L. L., Perry, J. R., Dillehay, D., Pearson, T. C., Waller, E. K., Larsen, C. P., Archer, D. R. (2002). A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex-mismatched bone marrow transplantation. Blood 99: 1840-1849 [Abstract] [Full Text]  
• Walters, M. C., Nienhuis, A. W., Vichinsky, E. (2002). Novel Therapeutic Approaches in Sickle Cell Disease. ASH Education Book 2002: 10-34 [Abstract] [Full Text]  
• Suzan, F., Ammor, M., Ribrag, V. (2001). Fatal Reactivation of Cytomegalovirus Infection after Use of Rituximab for a Post-Transplantation Lymphoproliferative Disorder. NEJM 345: 1000-1000 [Full Text]  
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