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Correspondence
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Volume 344:859-860 March 15, 2001 Number 11
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Biventricular Cardiac Thrombosis during Interleukin-2 Infusion

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To the Editor: We report on the phenomenon of intracardiac thrombosis with features of Löffler's syndrome observed in conjunction with interleukin-2 therapy.

Patient 1, a 26-year-old woman with stage IV Hodgkin's disease, began to receive a continuous infusion of recombinant human interleukin-2 (aldesleukin; Proleukin, Chiron) in an experimental outpatient protocol; the initial dose was 75,000 IU per kilogram of body weight per day and was increased weekly, as tolerated, to a maximum of 150,000 IU per kilogram per day. The patient had a corresponding increase in eosinophils in peripheral blood to a maximum of 11,400 cells per cubic millimeter.

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