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Correspondence
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Volume 344:936-937 March 22, 2001 Number 12
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Roads to Breast Cancer

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To the Editor: Dr. Haber (Nov. 23 issue)1 has provided a remarkably concise and clear discussion of the genetic defects that lead to breast cancer. I wish to stress that our understanding of defects in the BRCA1 and BRCA2 genes and in some other genes along these "roads" may have immediate practical application. In women with these genetic defects, there is a reduced ability to repair DNA double-strand breaks and other types of genetic damage.

Dr. Haber discusses errors in DNA caused by ionizing radiation or genotoxic drugs. Since radiation causes DNA damage, it follows that women who inherit defects . . . [Full Text of this Article]

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