FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 344:1058-1066 April 5, 2001 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Complement is part of the innate immune system and underlies one of the main effector mechanisms of antibody-mediated immunity. It has three overarching physiologic activities (Table 1): defending against pyogenic bacterial infection, bridging innate and adaptive immunity, and disposing of immune complexes and the products of inflammatory injury. In this review, each of these activities will be placed in a clinical context.

View this table: [in this window] [in a new window]   Table 1. The Three Main Physiologic Activities of the Complement System.

 
Complement was first identified as a heat-labile principle in serum that "complemented" antibodies in the killing of bacteria. We now know that complement is a system of . . . [Full Text of this Article]

Complement and the Defense against Infection

Pyogenic Infections

Complement Deficiency and Neisserial Infections

Mannose-Binding Lectin Deficiency

Complement and the Pathogenesis of Infectious Disease

Abnormalities of Complement Regulation

Activation of C3

C3 Nephritic Factor

Factor H Deficiency

C1 Inhibitor Deficiency

Paroxysmal Nocturnal Hemoglobinuria

Source Information

From the Rheumatology Section, Division of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Campus, London.

Address reprint requests to Dr. Walport at the Division of Medicine, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Rd., London W12 0NN, United Kingdom, or at m.walport@ic.ac.uk.

References

This article has been cited by other articles:

• Gorgani, N. N., He, J. Q., Katschke, K. J. Jr., Helmy, K. Y., Xi, H., Steffek, M., Hass, P. E., van Lookeren Campagne, M. (2008). Complement Receptor of the Ig Superfamily Enhances Complement-Mediated Phagocytosis in a Subpopulation of Tissue Resident Macrophages. J. Immunol. 181: 7902-7908 [Abstract] [Full Text]  
• Yu, Y., Huang, H., Wang, Y., Yu, Y., Yuan, S., Huang, S., Pan, M., Feng, K., Xu, A. (2008). A Novel C1q Family Member of Amphioxus Was Revealed to Have a Partial Function of Vertebrate C1q Molecule. J. Immunol. 181: 7024-7032 [Abstract] [Full Text]  
• Inomata, Y., Tanihara, H., Tanito, M., Okuyama, H., Hoshino, Y., Kinumi, T., Kawaji, T., Kondo, N., Yodoi, J., Nakamura, H. (2008). Suppression of Choroidal Neovascularization by Thioredoxin-1 via Interaction with Complement Factor H. IOVS 49: 5118-5125 [Abstract] [Full Text]  
• Gaarkeuken, H., Siezenga, M. A., Zuidwijk, K., van Kooten, C., Rabelink, T. J., Daha, M. R., Berger, S. P. (2008). Complement activation by tubular cells is mediated by properdin binding. Am. J. Physiol. Renal Physiol. 295: F1397-F1403 [Abstract] [Full Text]  
• Potempa, M., Potempa, J., Okroj, M., Popadiak, K., Eick, S., Nguyen, K.-A., Riesbeck, K., Blom, A. M. (2008). Binding of Complement Inhibitor C4b-Binding Protein Contributes to Serum Resistance of Porphyromonas gingivalis. J. Immunol. 181: 5537-5544 [Abstract] [Full Text]  
• Clay, C. D., Soni, S., Gunn, J. S., Schlesinger, L. S. (2008). Evasion of Complement-Mediated Lysis and Complement C3 Deposition Are Regulated by Francisella tularensis Lipopolysaccharide O Antigen. J. Immunol. 181: 5568-5578 [Abstract] [Full Text]  
• Liszewski, M. K., Bertram, P., Leung, M. K., Hauhart, R., Zhang, L., Atkinson, J. P. (2008). Smallpox Inhibitor of Complement Enzymes (SPICE): Regulation of Complement Activation on Cells and Mechanism of Its Cellular Attachment. J. Immunol. 181: 4199-4207 [Abstract] [Full Text]  
• Ramo, K., Cashman, S. M., Kumar-Singh, R. (2008). Evaluation of Adenovirus-Delivered Human CD59 as a Potential Therapy for AMD in a Model of Human Membrane Attack Complex Formation on Murine RPE. IOVS 49: 4126-4136 [Abstract] [Full Text]  
• Audard, V., Georges, B., Vanhille, P., Toly, C., Deroure, B., Fakhouri, F., Cuvelier, R., Belenfant, X., Surin, B., Aucouturier, P., Mougenot, B., Ronco, P. (2008). Renal Lesions Associated with IgM-Secreting Monoclonal Proliferations: Revisiting the Disease Spectrum. CJASN 3: 1339-1349 [Abstract] [Full Text]  
• Unsworth, D J (2008). Complement deficiency and disease. J. Clin. Pathol. 61: 1013-1017 [Abstract] [Full Text]  
• Zhou, X., Hu, W., Qin, X. (2008). The Role of Complement in the Mechanism of Action of Rituximab for B-Cell Lymphoma: Implications for Therapy. The Oncologist 13: 954-966 [Abstract] [Full Text]  
• Schmidt, C. Q., Herbert, A. P., Kavanagh, D., Gandy, C., Fenton, C. J., Blaum, B. S., Lyon, M., Uhrin, D., Barlow, P. N. (2008). A New Map of Glycosaminoglycan and C3b Binding Sites on Factor H. J. Immunol. 181: 2610-2619 [Abstract] [Full Text]  
• Wu, X., Spitzer, D., Mao, D., Peng, S. L., Molina, H., Atkinson, J. P. (2008). Membrane Protein Crry Maintains Homeostasis of the Complement System. J. Immunol. 181: 2732-2740 [Abstract] [Full Text]  
• Kim, D. D., Miwa, T., Kimura, Y., Schwendener, R. A., van Lookeren Campagne, M., Song, W.-C. (2008). Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg. Blood 112: 1109-1119 [Abstract] [Full Text]  
• Upadhyay, A., Burman, J. D., Clark, E. A., Leung, E., Isenman, D. E., van den Elsen, J. M. H., Bagby, S. (2008). Structure-Function Analysis of the C3 Binding Region of Staphylococcus aureus Immune Subversion Protein Sbi. J. Biol. Chem. 283: 22113-22120 [Abstract] [Full Text]  
• Yuste, J., Sen, A., Truedsson, L., Jonsson, G., Tay, L.-S., Hyams, C., Baxendale, H. E., Goldblatt, F., Botto, M., Brown, J. S. (2008). Impaired Opsonization with C3b and Phagocytosis of Streptococcus pneumoniae in Sera from Subjects with Defects in the Classical Complement Pathway. Infect. Immun. 76: 3761-3770 [Abstract] [Full Text]  
• Donev, R. M., Gray, L. C., Sivasankar, B., Hughes, T. R., van den Berg, C. W., Morgan, B. P. (2008). Modulation of CD59 Expression by Restrictive Silencer Factor-Derived Peptides in Cancer Immunotherapy for Neuroblastoma. Cancer Res. 68: 5979-5987 [Abstract] [Full Text]  
• Ben Nasr, A., Klimpel, G. R. (2008). Subversion of complement activation at the bacterial surface promotes serum resistance and opsonophagocytosis of Francisella tularensis. J. Leukoc. Biol. 84: 77-85 [Abstract] [Full Text]  
• Dechant, M., Weisner, W., Berger, S., Peipp, M., Beyer, T., Schneider-Merck, T., Lammerts van Bueren, J. J., Bleeker, W. K., Parren, P. W.H.I., van de Winkel, J. G.J., Valerius, T. (2008). Complement-Dependent Tumor Cell Lysis Triggered by Combinations of Epidermal Growth Factor Receptor Antibodies. Cancer Res. 68: 4998-5003 [Abstract] [Full Text]  
• Hallstrom, T., Zipfel, P. F., Blom, A. M., Lauer, N., Forsgren, A., Riesbeck, K. (2008). Haemophilus influenzae Interacts with the Human Complement Inhibitor Factor H. J. Immunol. 181: 537-545 [Abstract] [Full Text]  
• Beum, P. V., Lindorfer, M. A., Beurskens, F., Stukenberg, P. T., Lokhorst, H. M., Pawluczkowycz, A. W., Parren, P. W. H. I., van de Winkel, J. G. J., Taylor, R. P. (2008). Complement Activation on B Lymphocytes Opsonized with Rituximab or Ofatumumab Produces Substantial Changes in Membrane Structure Preceding Cell Lysis. J. Immunol. 181: 822-832 [Abstract] [Full Text]  
• Uria, M. J., Zhang, Q., Li, Y., Chan, A., Exley, R. M., Gollan, B., Chan, H., Feavers, I., Yarwood, A., Abad, R., Borrow, R., Fleck, R. A., Mulloy, B., Vazquez, J. A., Tang, C. M. (2008). A generic mechanism in Neisseria meningitidis for enhanced resistance against bactericidal antibodies. JEM 205: 1423-1434 [Abstract] [Full Text]  
• Xu, W., Berger, S. P., Trouw, L. A., de Boer, H. C., Schlagwein, N., Mutsaers, C., Daha, M. R., van Kooten, C. (2008). Properdin Binds to Late Apoptotic and Necrotic Cells Independently of C3b and Regulates Alternative Pathway Complement Activation. J. Immunol. 180: 7613-7621 [Abstract] [Full Text]  
• Stahl, A.-l., Vaziri-Sani, F., Heinen, S., Kristoffersson, A.-C., Gydell, K.-H., Raafat, R., Gutierrez, A., Beringer, O., Zipfel, P. F., Karpman, D. (2008). Factor H dysfunction in patients with atypical hemolytic uremic syndrome contributes to complement deposition on platelets and their activation. Blood 111: 5307-5315 [Abstract] [Full Text]  
• Kinderlerer, A. R., Ali, F., Johns, M., Lidington, E. A., Leung, V., Boyle, J. J., Hamdulay, S. S., Evans, P. C., Haskard, D. O., Mason, J. C. (2008). KLF2-dependent, Shear Stress-induced Expression of CD59: A NOVEL CYTOPROTECTIVE MECHANISM AGAINST COMPLEMENT-MEDIATED INJURY IN THE VASCULATURE. J. Biol. Chem. 283: 14636-14644 [Abstract] [Full Text]  
• Girgis, N. M., DeHaven, B. C., Fan, X., Viner, K. M., Shamim, M., Isaacs, S. N. (2008). Cell Surface Expression of the Vaccinia Virus Complement Control Protein Is Mediated by Interaction with the Viral A56 Protein and Protects Infected Cells from Complement Attack. J. Virol. 82: 4205-4214 [Abstract] [Full Text]  
• Takahashi, M., Iwaki, D., Kanno, K., Ishida, Y., Xiong, J., Matsushita, M., Endo, Y., Miura, S., Ishii, N., Sugamura, K., Fujita, T. (2008). Mannose-Binding Lectin (MBL)-Associated Serine Protease (MASP)-1 Contributes to Activation of the Lectin Complement Pathway. J. Immunol. 180: 6132-6138 [Abstract] [Full Text]  
• Brodsky, R. A. (2008). Narrative Review: Paroxysmal Nocturnal Hemoglobinuria: The Physiology of Complement-Related Hemolytic Anemia. ANN INTERN MED 148: 587-595 [Full Text]  
• Hocking, H. G., Herbert, A. P., Kavanagh, D., Soares, D. C., Ferreira, V. P., Pangburn, M. K., Uhrin, D., Barlow, P. N. (2008). Structure of the N-terminal Region of Complement Factor H and Conformational Implications of Disease-linked Sequence Variations. J. Biol. Chem. 283: 9475-9487 [Abstract] [Full Text]  
• Gomes, G. I., Nahn, E. P. Jr., Santos, R. K. R. G., Da Silva, W. D., Kipnis, T. L. (2008). The Functional State of the Complement System in Leprosy. Am J Trop Med Hyg 78: 605-610 [Abstract] [Full Text]  
• Kuo, C.-F., Lin, Y.-S., Chuang, W.-J., Wu, J.-J., Tsao, N. (2008). Degradation of Complement 3 by Streptococcal Pyrogenic Exotoxin B Inhibits Complement Activation and Neutrophil Opsonophagocytosis. Infect. Immun. 76: 1163-1169 [Abstract] [Full Text]  
• Peng, Q., Li, K., Anderson, K., Farrar, C. A., Lu, B., Smith, R. A. G., Sacks, S. H., Zhou, W. (2008). Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction. Blood 111: 2452-2461 [Abstract] [Full Text]  
• Marcheix, B., Carrier, M., Martel, C., Cossette, M., Pellerin, M., Bouchard, D., Perrault, L. P. (2008). Effect of Pericardial Blood Processing on Postoperative Inflammation and the Complement Pathways. Ann. Thorac. Surg. 85: 530-535 [Abstract] [Full Text]  
• Kimura, Y., Miwa, T., Zhou, L., Song, W.-C. (2008). Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement. Blood 111: 732-740 [Abstract] [Full Text]  
• Lewis, L. A., Ram, S., Prasad, A., Gulati, S., Getzlaff, S., Blom, A. M., Vogel, U., Rice, P. A. (2008). Defining Targets for Complement Components C4b and C3b on the Pathogenic Neisseriae. Infect. Immun. 76: 339-350 [Abstract] [Full Text]  
• Hammon, J. W. (2008). Extracorporeal Circulation: The Response of Humoral and Cellular Elements of Blood to Extracorporeal Circulation. Card Surg Adult 3: 370-389 [Full Text]  
• Poltermann, S., Kunert, A., von der Heide, M., Eck, R., Hartmann, A., Zipfel, P. F. (2007). Gpm1p Is a Factor H-, FHL-1-, and Plasminogen-binding Surface Protein of Candida albicans. J. Biol. Chem. 282: 37537-37544 [Abstract] [Full Text]  
• Hinson, S. R., Pittock, S. J., Lucchinetti, C. F., Roemer, S. F., Fryer, J. P., Kryzer, T. J., Lennon, V. A. (2007). Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica. Neurology 69: 2221-2231 [Abstract] [Full Text]  
• Roos, A., Daha, M. R., van Pelt, J., Berger, S. P. (2007). Mannose-binding lectin and the kidney. Nephrol Dial Transplant 22: 3370-3377 [Full Text]  
• Szeplaki, G., Varga, L., Laki, J., Dosa, E., Rugonfalvi-Kiss, S., Madsen, H. O., Prohaszka, Z., Kocsis, A., Gal, P., Szabo, A., Acsady, G., Karadi, I., Selmeci, L., Garred, P., Fust, G., Entz, L. (2007). Low C1-Inhibitor Levels Predict Early Restenosis After Eversion Carotid Endarterectomy. Arterioscler. Thromb. Vasc. Bio. 27: 2756-2762 [Abstract] [Full Text]  
• Reca, R., Cramer, D., Yan, J., Laughlin, M. J., Janowska-Wieczorek, A., Ratajczak, J., Ratajczak, M. Z. (2007). A Novel Role of Complement in Mobilization: Immunodeficient Mice Are Poor Granulocyte-Colony Stimulating Factor Mobilizers Because They Lack Complement-Activating Immunoglobulins. Stem Cells 25: 3093-3100 [Abstract] [Full Text]  
• Coffey, P. J., Gias, C., McDermott, C. J., Lundh, P., Pickering, M. C., Sethi, C., Bird, A., Fitzke, F. W., Maass, A., Chen, L. L., Holder, G. E., Luthert, P. J., Salt, T. E., Moss, S. E., Greenwood, J. (2007). Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction. Proc. Natl. Acad. Sci. USA 104: 16651-16656 [Abstract] [Full Text]  
• Fu, L., Garland, D., Yang, Z., Shukla, D., Rajendran, A., Pearson, E., Stone, E. M., Zhang, K., Pierce, E. A. (2007). The R345W mutation in EFEMP1 is pathogenic and causes AMD-like deposits in mice. Hum Mol Genet 16: 2411-2422 [Abstract] [Full Text]  
• Moskovich, O., Fishelson, Z. (2007). Live Cell Imaging of Outward and Inward Vesiculation Induced by the Complement C5b-9 Complex. J. Biol. Chem. 282: 29977-29986 [Abstract] [Full Text]  
• Janssen, B. J. C., Halff, E. F., Lambris, J. D., Gros, P. (2007). Structure of Compstatin in Complex with Complement Component C3c Reveals a New Mechanism of Complement Inhibition. J. Biol. Chem. 282: 29241-29247 [Abstract] [Full Text]  
• Jongerius, I., Kohl, J., Pandey, M. K., Ruyken, M., van Kessel, K. P.M., van Strijp, J. A.G., Rooijakkers, S. H.M. (2007). Staphylococcal complement evasion by various convertase-blocking molecules. JEM 204: 2461-2471 [Abstract] [Full Text]  
• Trouw, L. A., Bengtsson, A. A., Gelderman, K. A., Dahlback, B., Sturfelt, G., Blom, A. M. (2007). C4b-binding Protein and Factor H Compensate for the Loss of Membrane-bound Complement Inhibitors to Protect Apoptotic Cells against Excessive Complement Attack. J. Biol. Chem. 282: 28540-28548 [Abstract] [Full Text]  
• Banda, N. K., Takahashi, K., Wood, A. K., Holers, V. M., Arend, W. P. (2007). Pathogenic Complement Activation in Collagen Antibody- Induced Arthritis in Mice Requires Amplification by the Alternative Pathway. J. Immunol. 179: 4101-4109 [Abstract] [Full Text]  
• Hadders, M. A., Beringer, D. X., Gros, P. (2007). Structure of C8{alpha}-MACPF Reveals Mechanism of Membrane Attack in Complement Immune Defense. Science 317: 1552-1554 [Abstract] [Full Text]  
• Rooijakkers, S. H. M., Milder, F. J., Bardoel, B. W., Ruyken, M., van Strijp, J. A. G., Gros, P. (2007). Staphylococcal Complement Inhibitor: Structure and Active Sites. J. Immunol. 179: 2989-2998 [Abstract] [Full Text]  
• Markiewski, M. M., Lambris, J. D. (2007). The Role of Complement in Inflammatory Diseases From Behind the Scenes into the Spotlight. Am. J. Pathol. 171: 715-727 [Abstract] [Full Text]  
• Yates, J. R.W., Sepp, T., Matharu, B. K., Khan, J. C., Thurlby, D. A., Shahid, H., Clayton, D. G., Hayward, C., Morgan, J., Wright, A. F., Armbrecht, A. M., Dhillon, B., Deary, I. J., Redmond, E., Bird, A. C., Moore, A. T., the Genetic Factors in AMD Study Group, (2007). Complement C3 Variant and the Risk of Age-Related Macular Degeneration. NEJM 357: 553-561 [Abstract] [Full Text]  
• Griffin, R. S., Costigan, M., Brenner, G. J., Him Eddie Ma, C., Scholz, J., Moss, A., Allchorne, A. J., Stahl, G. L., Woolf, C. J. (2007). Complement Induction in Spinal Cord Microglia Results in Anaphylatoxin C5a-Mediated Pain Hypersensitivity. J. Neurosci. 27: 8699-8708 [Abstract] [Full Text]  
• Lenderink, A. M., Liegel, K., Ljubanovic, D., Coleman, K. E., Gilkeson, G. S., Holers, V. M., Thurman, J. M. (2007). The alternative pathway of complement is activated in the glomeruli and tubulointerstitium of mice with adriamycin nephropathy. Am. J. Physiol. Renal Physiol. 293: F555-F564 [Abstract] [Full Text]  
• Zhang, N., Truong-Tran, Q. A., Tancowny, B., Harris, K. E., Schleimer, R. P. (2007). Glucocorticoids Enhance or Spare Innate Immunity: Effects in Airway Epithelium Are Mediated by CCAAT/Enhancer Binding Proteins. J. Immunol. 179: 578-589 [Abstract] [Full Text]  
• Zhang, X., Kimura, Y., Fang, C., Zhou, L., Sfyroera, G., Lambris, J. D., Wetsel, R. A., Miwa, T., Song, W.-C. (2007). Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood 110: 228-236 [Abstract] [Full Text]  
• Jonsson, G., Sjoholm, A. G., Truedsson, L., Bengtsson, A. A., Braconier, J. H., Sturfelt, G. (2007). Rheumatological manifestations, organ damage and autoimmunity in hereditary C2 deficiency. Rheumatology (Oxford) 46: 1133-1139 [Abstract] [Full Text]  
• Herbert, A. P., Deakin, J. A., Schmidt, C. Q., Blaum, B. S., Egan, C., Ferreira, V. P., Pangburn, M. K., Lyon, M., Uhrin, D., Barlow, P. N. (2007). Structure Shows That a Glycosaminoglycan and Protein Recognition Site in Factor H Is Perturbed by Age-related Macular Degeneration-linked Single Nucleotide Polymorphism. J. Biol. Chem. 282: 18960-18968 [Abstract] [Full Text]  
• Nitsche-Schmitz, D. P., Johansson, H. M., Sastalla, I., Reissmann, S., Frick, I.-M., Chhatwal, G. S. (2007). Group G Streptococcal IgG Binding Molecules FOG and Protein G Have Different Impacts on Opsonization by C1q. J. Biol. Chem. 282: 17530-17536 [Abstract] [Full Text]  
• van Montfoort, N., de Jong, J. M. H., Schuurhuis, D. H., van der Voort, E. I. H., Camps, M. G. M., Huizinga, T. W. J., van Kooten, C., Daha, M. R., Verbeek, J. S., Ossendorp, F., Toes, R. E. M. (2007). A Novel Role of Complement Factor C1q in Augmenting the Presentation of Antigen Captured in Immune Complexes to CD8+ T Lymphocytes. J. Immunol. 178: 7581-7586 [Abstract] [Full Text]  
• Katschke, K. J. Jr., Helmy, K. Y., Steffek, M., Xi, H., Yin, J., Lee, W. P., Gribling, P., Barck, K. H., Carano, R. A.D., Taylor, R. E., Rangell, L., Diehl, L., Hass, P. E., Wiesmann, C., van Lookeren Campagne, M. (2007). A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis. JEM 204: 1319-1325 [Abstract] [Full Text]  
• Star, L., Frankena, K., Kemp, B., Nieuwland, M. G. B., Parmentier, H. K. (2007). Natural Humoral Immune Competence and Survival in Layers. Poult. Sci. 86: 1090-1099 [Abstract] [Full Text]  
• Popadiak, K., Potempa, J., Riesbeck, K., Blom, A. M. (2007). Biphasic Effect of Gingipains from Porphyromonas gingivalis on the Human Complement System. J. Immunol. 178: 7242-7250 [Abstract] [Full Text]  
• Ma, B. Y., Nakamura, N., Dlabac, V., Naito, H., Yamaguchi, S., Ishikawa, M., Nonaka, M., Ishiguro, M., Kawasaki, N., Oka, S., Kawasaki, T. (2007). Isolation, Cloning, and Characterization of a Novel Phosphomannan-binding Lectin from Porcine Serum. J. Biol. Chem. 282: 12963-12975 [Abstract] [Full Text]  
• Alexander, J. J., Wang, Y., Chang, A., Jacob, A., Minto, A. W.M., Karmegam, M., Haas, M., Quigg, R. J. (2007). Mouse Podocyte Complement Factor H: The Functional Analog to Human Complement Receptor 1. J. Am. Soc. Nephrol. 18: 1157-1166 [Abstract] [Full Text]  
• Bao, L., Wang, Y., Chang, A., Minto, A. W., Zhou, J., Kang, H., Haas, M., Quigg, R. J. (2007). Unrestricted C3 Activation Occurs in Crry-Deficient Kidneys and Rapidly Leads to Chronic Renal Failure. J. Am. Soc. Nephrol. 18: 811-822 [Abstract] [Full Text]  
• Nishimura, T., Myles, T., Piliposky, A. M., Kao, P. N., Berry, G. J., Leung, L. L. K. (2007). Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo. Blood 109: 1992-1997 [Abstract] [Full Text]  
• Bok, D. (2007). Contributions of Genetics to Our Understanding of Inherited Monogenic Retinal Diseases and Age-Related Macular Degeneration. Arch Ophthalmol 125: 160-164 [Abstract] [Full Text]  
• Rupprecht, T. A., Angele, B., Klein, M., Heesemann, J., Pfister, H.-W., Botto, M., Koedel, U. (2007). Complement C1q and C3 Are Critical for the Innate Immune Response to Streptococcus pneumoniae in the Central Nervous System. J. Immunol. 178: 1861-1869 [Abstract] [Full Text]  
• Ho, D. K., Ram, S., Nelson, K. L., Bonthuis, P. J., Smith, A. L. (2007). lgtC Expression Modulates Resistance to C4b Deposition on an Invasive Nontypeable Haemophilus influenzae. J. Immunol. 178: 1002-1012 [Abstract] [Full Text]  
• Bhatia, V. K., Yun, S., Leung, V., Grimsditch, D. C., Benson, G. M., Botto, M. B., Boyle, J. J., Haskard, D. O. (2007). Complement C1q Reduces Early Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. Am. J. Pathol. 170: 416-426 [Abstract] [Full Text]  
• Nishida, N., Walz, T., Springer, T. A. (2006). Structural transitions of complement component C3 and its activation products. Proc. Natl. Acad. Sci. USA 103: 19737-19742 [Abstract] [Full Text]  
• Schepers, A., de Vries, M.R., van Leuven, C.J., Grimbergen, J.M., Holers, V.M., Daha, M.R., van Bockel, J.H., Quax, P.H.A. (2006). Inhibition of Complement Component C3 Reduces Vein Graft Atherosclerosis in Apolipoprotein E3-Leiden Transgenic Mice. Circulation 114: 2831-2838 [Abstract] [Full Text]  
• Iwaki, D., Kanno, K., Takahashi, M., Endo, Y., Lynch, N. J., Schwaeble, W. J., Matsushita, M., Okabe, M., Fujita, T. (2006). Small Mannose-Binding Lectin-Associated Protein Plays a Regulatory Role in the Lectin Complement Pathway. J. Immunol. 177: 8626-8632 [Abstract] [Full Text]  
• Chung, K. M., Liszewski, M. K., Nybakken, G., Davis, A. E., Townsend, R. R., Fremont, D. H., Atkinson, J. P., Diamond, M. S. (2006). From the Cover: West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H. Proc. Natl. Acad. Sci. USA 103: 19111-19116 [Abstract] [Full Text]  
• Schlesinger, J. J. (2006). Flavivirus nonstructural protein NS1: Complementary surprises. Proc. Natl. Acad. Sci. USA 103: 18879-18880 [Full Text]  
• Dragun, D. (2006). Complement-ary matching: a definite maybe. Nephrol Dial Transplant 21: 3371-3373 [Full Text]  
• Hartwig, W., Klafs, M., Kirschfink, M., Hackert, T., Schneider, L., Gebhard, M.-M., Buchler, M. W., Werner, J. (2006). Interaction of complement and leukocytes in severe acute pancreatitis: potential for therapeutic intervention.. Am. J. Physiol. Gastrointest. Liver Physiol. 291: G844-G850 [Abstract] [Full Text]  
• Nakao, M., Kajiya, T., Sato, Y., Somamoto, T., Kato-Unoki, Y., Matsushita, M., Nakata, M., Fujita, T., Yano, T. (2006). Lectin Pathway of Bony Fish Complement: Identification of Two Homologs of the Mannose-Binding Lectin Associated with MASP2 in the Common Carp (Cyprinus carpio). J. Immunol. 177: 5471-5479 [Abstract] [Full Text]  
• Kim, D. D., Miwa, T., Song, W.-C. (2006). Retrovirus-Mediated Over-Expression of Decay-Accelerating Factor Rescues Crry-Deficient Erythrocytes from Acute Alternative Pathway Complement Attack. J. Immunol. 177: 5558-5566 [Abstract] [Full Text]  
• Hansen, T. K., Gall, M.-A., Tarnow, L., Thiel, S., Stehouwer, C. D., Schalkwijk, C. G., Parving, H.-H., Flyvbjerg, A. (2006). Mannose-binding lectin and mortality in type 2 diabetes.. Arch Intern Med 166: 2007-2013 [Abstract] [Full Text]  
• Loo, L. S., McNamara, J. O. (2006). Impaired Volume Regulation is the Mechanism of Excitotoxic Sensitization to Complement. J. Neurosci. 26: 10177-10187 [Abstract] [Full Text]  
• Storini, C., Bergamaschini, L., Gesuete, R., Rossi, E., Maiocchi, D., De Simoni, M. G. (2006). Selective Inhibition of Plasma Kallikrein Protects Brain from Reperfusion Injury. J. Pharmacol. Exp. Ther. 318: 849-854 [Abstract] [Full Text]  
• Jonsson, G., Oxelius, V.-A., Truedsson, L., Braconier, J. H., Sturfelt, G., Sjoholm, A. G. (2006). Homozygosity for the IgG2 Subclass Allotype G2M(n) Protects against Severe Infection in Hereditary C2 Deficiency. J. Immunol. 177: 722-728 [Abstract] [Full Text]  
• Abrera-Abeleda, M A, Nishimura, C, Smith, J L H, Sethi, S, McRae, J L, Murphy, B F, Silvestri, G, Skerka, C, Jozsi, M, Zipfel, P F, Hageman, G S, Smith, R J H (2006). Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease). J. Med. Genet. 43: 582-589 [Abstract] [Full Text]  
• Fremeaux-Bacchi, V., Moulton, E. A., Kavanagh, D., Dragon-Durey, M.-A., Blouin, J., Caudy, A., Arzouk, N., Cleper, R., Francois, M., Guest, G., Pourrat, J., Seligman, R., Fridman, W. H., Loirat, C., Atkinson, J. P. (2006). Genetic and Functional Analyses of Membrane Cofactor Protein (CD46) Mutations in Atypical Hemolytic Uremic Syndrome. J. Am. Soc. Nephrol. 17: 2017-2025 [Abstract] [Full Text]  
• Herbert, A. P., Uhrin, D., Lyon, M., Pangburn, M. K., Barlow, P. N. (2006). Disease-associated Sequence Variations Congregate in a Polyanion Recognition Patch on Human Factor H Revealed in Three-dimensional Structure. J. Biol. Chem. 281: 16512-16520 [Abstract] [Full Text]  
• Schneider, M. C., Exley, R. M., Chan, H., Feavers, I., Kang, Y.-H., Sim, R. B., Tang, C. M. (2006). Functional Significance of Factor H Binding to Neisseria meningitidis.. J. Immunol. 176: 7566-7575 [Abstract] [Full Text]  
• Brown, K. M., Kondeatis, E., Vaughan, R. W., Kon, S. P., Farmer, C. K.T., Taylor, J. D., He, X., Johnston, A., Horsfield, C., Janssen, B. J.C., Gros, P., Zhou, W., Sacks, S. H., Sheerin, N. S. (2006). Influence of donor C3 allotype on late renal-transplantation outcome.. NEJM 354: 2014-2023 [Abstract] [Full Text]  
• Zhang, L., Morikis, D. (2006). Immunophysical Properties and Prediction of Activities for Vaccinia Virus Complement Control Protein and Smallpox Inhibitor of Complement Enzymes Using Molecular Dynamics and Electrostatics. Biophys. J 90: 3106-3119 [Abstract] [Full Text]  
• Alexander, J. J., Aneziokoro, O.G.B., Chang, A., Hack, B. K., Markaryan, A., Jacob, A., Luo, R., Thirman, M., Haas, M., Quigg, R. J. (2006). Distinct and Separable Roles of the Complement System in Factor H-Deficient Bone Marrow Chimeric Mice with Immune Complex Disease. J. Am. Soc. Nephrol. 17: 1354-1361 [Abstract] [Full Text]  
• Takahashi, M., Iwaki, D., Matsushita, A., Nakata, M., Matsushita, M., Endo, Y., Fujita, T. (2006). Cloning and characterization of mannose-binding lectin from lamprey (agnathans).. J. Immunol. 176: 4861-4868 [Abstract] [Full Text]