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Previous Volume 344:1099-1100 April 5, 2001 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: A 25-year-old man with fistulizing Crohn's disease began to have high fever, dyspnea, and a productive cough five days after he received a single intravenous dose of 5 mg of a monoclonal antibody against tumor necrosis factor (anti–TNF- antibody; infliximab, Centocor, Malvern, Pa.) per kilogram of body weight. His current medications did not include corticosteroids or other immunosuppressive drugs. His chest roentgenogram showed massive, bilateral infiltrates, and laboratory examination revealed an elevated C-reactive protein value and leukocytosis. He received treatment with intravenous broad-spectrum antibiotics. Within 24 hours after admission, respiratory insufficiency developed. Ventilatory support and extracorporeal membrane . . . [Full Text of this Article]

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