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Previous Volume 344:1222-1231 April 19, 2001 Number 16 Next

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The annual incidence of venous thrombosis, one of the leading causes of mortality and morbidity, increases from 1 per 100,000 during childhood to 1 per 100 in old age.¹ In this article we will discuss conditions involving a genetic predisposition to venous thrombosis. The clinical relevance of this topic has increased with new evidence of the high prevalence of mutant genes that increase susceptibility to thrombosis.

Of the three mechanisms of thrombosis defined by Virchow in the 19th century — vessel-wall injury, stasis, and "changes in the composition of blood" (hypercoagulability) — the last two predominate in venous thrombosis. Hypercoagulability . . . [Full Text of this Article]

Historical Perspective

Mechanisms of Thrombosis in Inherited Thrombophilia

Epidemiologic and Genetic Features of Inherited Thrombophilia

Clinical Features of Inherited Thrombophilia

Recurrent Venous Thrombosis

Inherited Thrombophilias during Pregnancy and the Puerperium

Oral Contraceptives and Hormone-Replacement Therapy

Diagnosis of Inherited Thrombophilia

Therapy and Prophylaxis

Source Information

From the Institute of Thrombosis and Hemostasis and the National Hemophilia Center, Department of Hematology, Chaim Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv — both in Israel.

Address reprint requests to Dr. Seligsohn at the Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel, or at zeligson@post.tau.ac.il.

References

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• Heil, J. W., Malinowski, L., Rinderknecht, A., Broderick, J. P., Franz, D. (2008). Use of Intravenous Tissue Plasminogen Activator in a 16-Year-Old Patient with Basilar Occlusion. J Child Neurol 23: 1049-1053 [Abstract]  
• Nelson, S. M., Greer, I. A. (2008). The potential role of heparin in assisted conception. Hum Reprod Update 0: dmn031v1-23 [Abstract] [Full Text]  
• De Sutter, P., Gerris, J., Dhont, M. (2008). Assisted reproductive technologies: how to minimize the risks and complications in developing countries?. ESHRE Monogr 2008: 73-76 [Abstract] [Full Text]  
• Okumus, G., Kiyan, E., Arseven, O., Tabak, L., Diz-Kucukkaya, R., Unlucerci, Y., Abaci, N., Unaltuna, N. E., Issever, H. (2008). Hereditary Thrombophilic Risk Factors and Venous Thromboembolism in Istanbul, Turkey: The Role in Different Clinical Manifestations of Venous Thromboembolism. CLIN APPL THROMB HEMOST 14: 168-173 [Abstract]  
• Sniecinski, R., Szlam, F., Chen, E. P., Bader, S. O., Levy, J. H., Tanaka, K. A. (2008). Antithrombin Deficiency Increases Thrombin Activity After Prolonged Cardiopulmonary Bypass. Anesth. Analg. 106: 713-718 [Abstract] [Full Text]  
• Stone, M. E., Silverman, S. H., Nomoto, K. (2007). Intracardiac Thrombosis and Acute Right Ventricular Failure Following Complex Reoperative Cardiac Surgery With Aprotinin and Deep Hypothermic Circulatory Arrest. SEMIN CARDIOTHORAC VASC ANESTH 11: 177-184 [Abstract]  
• Yegen, H. A., Lederer, D. J., Barr, R. G., Wilt, J. S., Fang, Y., Bagiella, E., D'Ovidio, F., Okun, J. M., Sonett, J. R., Arcasoy, S. M., Kawut, S. M. (2007). Risk Factors for Venous Thromboembolism After Lung Transplantation. Chest 132: 547-553 [Abstract] [Full Text]  
• Passamonti, F., Randi, M. L., Rumi, E., Pungolino, E., Elena, C., Pietra, D., Scapin, M., Arcaini, L., Tezza, F., Moratti, R., Pascutto, C., Fabris, F., Morra, E., Cazzola, M., Lazzarino, M. (2007). Increased risk of pregnancy complications in patients with essential thrombocythemia carrying the JAK2 (617V>F) mutation. Blood 110: 485-489 [Abstract] [Full Text]  
• Corral, J., Hernandez-Espinosa, D., Soria, J. M., Gonzalez-Conejero, R., Ordonez, A., Gonzalez-Porras, J. R., Perez-Ceballos, E., Lecumberri, R., Sanchez, I., Roldan, V., Mateo, J., Minano, A., Gonzalez, M., Alberca, I., Fontcuberta, J., Vicente, V. (2007). Antithrombin Cambridge II (A384S): an underestimated genetic risk factor for venous thrombosis. Blood 109: 4258-4263 [Abstract] [Full Text]  
• Dent, G. A., Herman, J. H., Siegel, J. E. (2007). Laboratory hematology. ASH-SAP 2007: 444-465 [Full Text]  
• Morozowich, S. T., Donahue, B. S., Welsby, I. J. (2006). Genetics of coagulation: considerations for cardiac surgery.. SEMIN CARDIOTHORAC VASC ANESTH 10: 297-313 [Abstract]  
• Altomare, I., Aledort, L. M. (2006). Is Homozygosity for the MTHFR C677T Mutation a Risk Factor for Miscarriage? -- Likely.. ASH ANNUAL MEETING ABSTRACTS 108: 4079-4079 [Abstract] [Full Text]  
• Hartel, C., Konig, I., Koster, S., Kattner, E., Kuhls, E., Kuster, H., Moller, J., Muller, D., Kribs, A., Segerer, H., Wieg, C., Herting, E., Gopel, W. (2006). Genetic Polymorphisms of Hemostasis Genes and Primary Outcome of Very Low Birth Weight Infants. Pediatrics 118: 683-689 [Abstract] [Full Text]  
• Winyard, P J D, Bharucha, T, De Bruyn, R, Dillon, M J, van't Hoff, W, Trompeter, R S, Liesner, R, Wade, A, Rees, L (2006). Perinatal renal venous thrombosis: presenting renal length predicts outcome. Arch. Dis. Child. Fetal Neonatal Ed. 91: F273-F278 [Abstract] [Full Text]  
• Naeem, M. A., Anwar, M., Ali, W., Ayyub, M., Nasiruddin, (2006). Prevalence of Prothrombin Gene Mutation (G-A 20210 A) in General Population: A Pilot Study. CLIN APPL THROMB HEMOST 12: 223-226 [Abstract]  
• Dentali, F., Crowther, M., Ageno, W. (2006). Thrombophilic abnormalities, oral contraceptives, and risk of cerebral vein thrombosis: a meta-analysis. Blood 107: 2766-2773 [Abstract] [Full Text]  
• Robinson, G. V (2006). Pulmonary embolism in hospital practice. BMJ 332: 156-160 [Full Text]  
• Lee, R. V. (2005). Thromboembolism in Pregnancy: A Continuing Conundrum. ANN INTERN MED 143: 749-750 [Full Text]  
• Sucker, C., Farokhzad, F., Kurschat, C., Grabensee, B., Stockschlaeder, M., Zotz, R. B., Scharf, R. E. (2005). High clotting factor activities and enhanced platelet-related haemostasis in a patient with recurrent episodes of thrombotic-thrombocytopenic purpura: additional risk factors for onset and recurrence?. Nephrol Dial Transplant 20: 1515-1516 [Full Text]  
• Beck, M. J., Berman, B. (2005). Review of Thrombophilic States. CLIN PEDIATR 44: 193-199  
• Haines, S. T., Nutescu, E. A. (2005). Current and emerging treatment options for venous thrombosis: A case discussion. Am J Health Syst Pharm 62: 593-605 [Full Text]  
• Johnson, C. M., Mureebe, L., Silver, D. (2005). Hypercoagulable States: A Review. VASC ENDOVASCULAR SURG 39: 123-133 [Abstract]  
• Mandala, M., Curigliano, G., Bucciarelli, P., Ferretti, G., Mannucci, P. M., Colleoni, M., Ventura, A., Peruzzotti, G., Severi, G., Pelicci, P. G., Biffi, R., Orsi, F., Cinieri, S., Goldhirsch, A. (2004). Factor V Leiden and G20210A prothrombin mutation and the risk of subclavian vein thrombosis in patients with breast cancer and a central venous catheter. Ann Oncol 15: 590-593 [Abstract] [Full Text]  
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• Elias, E. R. (2003). Genetic Evaluation in the Newborn. NeoReviews 4: e277-282 [Full Text]  
• Frazee, L. A, Chomo, D. L (2003). Duration of Anticoagulant Therapy After Initial Idiopathic Venous Thromboembolism. The Annals of Pharmacotherapy 37: 1489-1496 [Abstract] [Full Text]  
• Ryan, M F, Murphy, J P, Jay, R, Callum, J, MacDonald, D (2003). MRI diagnosis of bilateral adrenal vein thrombosis. Br. J. Radiol. 76: 566-569 [Abstract] [Full Text]  
• Hankey, G. J., Eikelboom, J. W. (2003). Editorial Comment--Routine Thrombophilia Testing in Stroke Patients Is Unjustified. Stroke 34: 1826-1827 [Full Text]  
• (2003). British Thoracic Society guidelines for the management of suspected acute pulmonary embolism. Thorax 58: 470-483 [Full Text]  
• LaPorte, D., Farber, S., Sorin, S., Wahba, S., Daneels, E., Korzenko, A., Kopes-Kerr, C. P. (2003). When Deep Venous Thrombosis Fails to Respond to Therapy. J Am Board Fam Med 16: 246-250 [Abstract] [Full Text]  
• Streiff, M. B. (2003). Vena Caval Filters: A Review for Intensive Care Specialists. J Intensive Care Med 18: 59-79 [Abstract]  
• Journeycake, J. M., Buchanan, G. R. (2003). Coagulation Disorders. Pediatr. Rev. 24: 83-91 [Full Text]  
• Eckman, M. H., Erban, J. K., Singh, S. K., Kao, G. S. (2003). Screening for the Risk for Bleeding or Thrombosis. ANN INTERN MED 138: W-15-W-24 [Abstract] [Full Text]  
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• Lindhoff-Last, E., Wenning, B., Stein, M., Gerdsen, F., Bauersachs, R., Wagnert, R. (2002). Risk Factors and Long-term Follow-up of Patients with the Immune Type of Heparin-Induced Thrombocytopenia. CLIN APPL THROMB HEMOST 8: 347-352 [Abstract]  
• Joffe, H. V., Goldhaber, S. Z. (2002). Upper-Extremity Deep Vein Thrombosis. Circulation 106: 1874-1880 [Full Text]  
• Hresko, M. T., McDougall, P. A., Gorlin, J. B., Vamvakas, E. C., Kasser, J. R., Neufeld, E. J. (2002). Prospective Reevaluation of the Association Between Thrombotic Diathesis and Legg-Perthes Disease. JBJS 84: 1613-1618 [Abstract] [Full Text]  
• Evans, J. G., Lee-Tataseo, C. (2002). Determination of the Factor V Leiden Single-Nucleotide Polymorphism in a Commercial Clinical Laboratory by Use of NanoChip Microelectronic Array Technology. Clin. Chem. 48: 1406-1411 [Abstract] [Full Text]  
• Procopiou, M. (2002). Genetic Hypercoagulability Syndromes: Does Testing Really Matter?. Arch Intern Med 162: 1784-1785 [Full Text]  
• Goichot, B., Perrin, A.-E., Thomas, R. H. (2002). Hypercoagulable Disorders. Arch Intern Med 162: 1785-1787 [Full Text]  
• Murphy, K. M., Eshleman, J. R. (2002). Simultaneous Sequencing of Multiple Polymerase Chain Reaction Products and Combined Polymerase Chain Reaction with Cycle Sequencing in Single Reactions. Am. J. Pathol. 161: 27-33 [Abstract] [Full Text]  
• Joffe, H. V, Goldhaber, S. Z (2002). Laboratory thrombophilias and venous thromboembolism. Vasc Med 7: 93-102 [Abstract]  
• Kovacs, M. J., Federman, D. G., Kirsner, R. S. (2002). Timing of Hypercoagulable Screens. Arch Intern Med 162: 613-614 [Full Text]  
• Rossouw, J. E (2002). Hormones, genetic factors, and gender differences in cardiovascular disease. Cardiovasc Res 53: 550-557 [Full Text]  
• Rasche, H. (2001). Haemostasis and thrombosis: an overview. Eur Heart J Suppl 3: Q3-Q7 [Abstract]  
• Caplin, N., Edelman, L., Casals Sole, F. J., Potzsch, B., Madlener, K., Goichot, B., Andres, E., Seligsohn, U., Lubetsky, A. (2001). Thrombophilia. NEJM 345: 697-699 [Full Text]