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Correspondence
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Volume 344:1254 April 19, 2001 Number 16
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Chromosomal Abnormalities in Chronic Lymphocytic Leukemia

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To the Editor: Döhner and colleagues (Dec. 28 issue)1 report that in a study of chromosomal abnormalities in patients with chronic lymphocytic leukemia, patients with 17p deletions had a poor prognosis, with a median survival time of 32 months. Of the 325 patients enrolled in the study, 77 (24 percent) had received prior chemotherapy. Although prior chemotherapy is not reported as a prognostic factor in this study, it is the standard of care for patients with advanced disease. Therefore, the high percentage of previously treated patients may have had a confounding effect on this important analysis. Can the authors state . . . [Full Text of this Article]

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