Molecular Markers of the Risk of Oral Cancer

doi:10.1056/NEJM200104263441710

Volume 344:1323-1326		April 26, 2001		Number 17

Molecular Markers of the Risk of Oral Cancer

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Oral cancer is the most common neoplasm of the head and neck.Worldwide, the annual incidence of new cases exceeds 300,000.The disease causes great morbidity, and the five-year survivalrate of less than 50 percent has not improved in more than twodecades.¹ New approaches for controlling this cancer includeprevention and early detection in patients with oral leukoplakia(Figure 1), the most common premalignant lesion of the oralcavity. Although the incidence of oral leukoplakia (white patches)is virtually impossible to ascertain, it surely exceeds theincidence of oral cancer. Leukoplakia is a marker of an . . . [Full Text of this Article]

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