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Previous Volume 344:1332-1333 April 26, 2001 Number 17 Next

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To the Editor: Allergic symptoms are the result of an inflammatory process triggered by an allergen or allergens to which a patient has generated antibodies after a previous exposure. Dr. Kay's review article on allergic diseases (Jan. 4 issue)¹ recognizes only the action of IgE in the inflammatory process and erroneously identifies a response mediated by type 2 helper T cells (Th2) as an exclusively IgE response, ignoring the other epitopes. This may be the result of using immediate hypersensitivity skin-prick tests as the sole means to detect the patient's allergic reactivities. Such tests detect only IgE antibodies. I believe . . . [Full Text of this Article]

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