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Previous Volume 344:1378-1388 May 3, 2001 Number 18 Next

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Reports of illness resembling meningococcal disease date back to the 16th century. The description reported by Vieusseux in 1805 is generally thought to be the first definitive identification of the disease,¹ and the causative organism, Neisseria meningitidis, was first isolated in 1887.² Yet meningococcal disease remains a leading cause of bacterial meningitis and sepsis in the United States and a major cause of epidemics in sub-Saharan Africa. Short of abolishing tobacco use, which is thought to be responsible for almost one third of cases,³ routine vaccination of high-risk populations is likely to be the most effective public health strategy . . . [Full Text of this Article]

Epidemiologic Features of Meningococcal Disease

In the United States

Worldwide

Microbiologic Features and Pathogenesis

Risk Factors

Clinical Manifestations

Diagnosis

Management

Control and Prevention

Chemoprophylaxis

Meningococcal Polysaccharide Vaccine

Improved Vaccines

Conclusions

Source Information

From the Meningitis and Special Pathogens Branch, Division of Bacterial and Mycotic Diseases (N.E.R., B.A.P., D.S.S., T.P.), National Center for Infectious Diseases (J.M.H.), Centers for Disease Control and Prevention; and Emory University School of Medicine (D.S.S.) — both in Atlanta.

Address reprint requests to Dr. Rosenstein at the Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd. N.E., Mailstop C-09, Atlanta, GA 30333, or at nar5@cdc.gov.

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