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Previous Volume 344:1560 May 17, 2001 Number 20 Next

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(Advances in Vascular Biology. Vol. 6.) Edited by Michael C. Berndt. 339 pp., illustrated. Amsterdam, Harwood Academic, 2000. $90. ISBN 90-5702-369-5.

This book discusses key aspects of platelet function in the regulation of hemostasis and thrombosis. It covers topics ranging from the platelet cytoskeleton to the antiphospholipid-antibody syndrome. Among the many highlights of the book is the section on von Willebrand's disease, a group of quantitative and qualitative abnormalities of von Willebrand factor. These abnormalities are the most common causes of inherited bleeding disorders, with a prevalence of up to 1 percent of the population. The defect in primary hemostasis results from a failure of platelet adhesion at the site of vascular damage. New ways of classifying von Willebrand's disease according . . . [Full Text of this Article]

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