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Previous Volume 344:1784-1785 June 7, 2001 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In this issue of the Journal, Arafah presents data indicating that some women with hypothyroidism receiving thyroxine therapy needed more thyroxine when they received estrogen therapy — a change caused by an estrogen-induced increase in the serum concentration of thyroxine-binding globulin.¹ The increased need for thyroxine occurred in women with hypothyroidism who were receiving moderate doses of thyroxine, intended to replace normal thyroxine secretion and restore thyrotropin secretion to normal, and in women with thyroid carcinoma who were receiving higher doses of thyroxine, intended to suppress thyrotropin secretion to below normal.

Thyroxine-binding globulin is a glycoprotein produced in the liver . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Centanni, M., Gargano, L., Canettieri, G., Viceconti, N., Franchi, A., Fave, G. D., Annibale, B. (2006). Thyroxine in goiter, Helicobacter pylori infection, and chronic gastritis.. NEJM 354: 1787-1795 [Abstract] [Full Text]  
• Qatanani, M., Zhang, J., Moore, D. D. (2005). Role of the Constitutive Androstane Receptor in Xenobiotic-Induced Thyroid Hormone Metabolism. Endocrinology 146: 995-1002 [Abstract] [Full Text]