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Correspondence
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Volume 344:1870-1871 June 14, 2001 Number 24
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Creation of a Double Chimera after the Transplantation of Umbilical-Cord Blood from Two Partially Matched Unrelated Donors

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To the Editor: Despite promising outcomes in the transplantation into pediatric recipients of umbilical-cord blood from unrelated donors, the low cell dose adversely affects both the rate of hematopoietic recovery and the probability of survival.1,2,3 The cell dose is a major limitation of the procedure, particularly in adults. An alternative to the ex vivo expansion of cells, which has yet to be shown to be efficacious, is the transplantation of 2 closely HLA-matched units of umbilical-cord blood.

We transplanted 2 units of umbilical-cord blood from male infant donors into a 53-year-old, 84-kg woman with accelerated-phase chronic myelogenous leukemia and no . . . [Full Text of this Article]

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