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Previous Volume 344:2028-2029 June 28, 2001 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The sample set used by Hedenfalk et al. (Feb. 22 issue)¹ may not be representative of the natural distribution of the characteristics of tumors with BRCA1 mutations, tumors with BRCA2 mutations, and sporadic cases of breast cancer. The proportions of tumors with BRCA1 mutations and tumors with BRCA2 mutations that are reported to be negative or positive for estrogen receptors vary widely depending on age and ethnic background of the study cohort.² Human mammary glands contain two distinct types of epithelial cells, basal and luminal. Perou and colleagues³ have suggested that estrogen-receptor–negative cancers encompass at least three . . . [Full Text of this Article]

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