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Previous Volume 344:229-230 January 18, 2001 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Jacobs et al. (Sept. 28 issue)¹ suggest that interferon beta-1a therapy for some patients with a first clinically isolated syndrome of multiple sclerosis may delay the onset of clinically definite multiple sclerosis. The diagnosis of multiple sclerosis has long been based on dissemination in both space and time. If this approach still holds, can a valid assessment of a potential disorder be made before the appearance of the symptoms that define it? I find this study troubling for several reasons.

Optic neuritis is easy to identify, but no criteria are given for "incomplete transverse myelitis." Is it . . . [Full Text of this Article]

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