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Previous Volume 344:270-274 January 25, 2001 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Autoimmune polyglandular syndrome type I is an autosomal recessive inherited disease caused by mutations in the autoimmune regulator gene.¹ Its hallmarks are the failure of multiple endocrine glands due to an autoimmune process, susceptibility to chronic candida infection because of a T-cell defect, and dystrophy of ectodermal tissues.² The most common endocrine manifestations are hypoparathyroidism and adrenal failure. Hypogonadism, hypothyroidism, type 1 diabetes mellitus, and hypopituitarism may also occur. Nonendocrine manifestations include enamel hypoplasia, nail dystrophy, keratoconjunctivitis, and pernicious anemia.^2,3 Except for candidiasis, patients with this syndrome have no apparent susceptibility to infections.

About 20 percent of patients with autoimmune . . . [Full Text of this Article]

Case Report

Results

Discussion

Source Information

From the Departments of Internal Medicine (C.H., K.H.L., C.A.S.A., J.L.P., J.S.F.) and Pathology (R.L.M., G.J.N., D.B.), Baylor University Medical Center, Dallas; and the Deaconess Billings Clinic, Billings, Mont. (L.F.).

Address reprint requests to Dr. Fordtran at Baylor University Medical Center, 3500 Gaston Ave., Dallas, TX 75246.

References

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