Asthma is a complex syndrome with many clinical phenotypes inboth adults and children. Its major characteristics includea variable degree of airflow obstruction, bronchial hyperresponsiveness,and airway inflammation. For many patients, the disease hasits roots in infancy, and both genetic factors (atopy)1,2 andenvironmental factors (viruses,3 allergens,4 and occupationalexposures5) contribute to its inception and evolution. To comprehendthe pathogenetic mechanisms underlying the many variants ofasthma, it is essential to identify factors that initiate, intensify,and modulate the inflammatory response of the airway and todetermine how these immunologic and biologic processes producethe characteristic airway . . . [Full Text of this Article]
Immunohistopathology of Asthma
Allergic Inflammation in Asthma
Mast Cells
Eosinophils
Lymphocytes
An Imbalance between Th1 and Th2 Cells and the Origins of Asthma
Airway Remodeling in Asthma
Therapy
Conclusions
Source Information
From the Departments of Medicine (W.W.B.) and Pediatrics (R.F.L.), University of Wisconsin, Madison.
Address reprint requests to Dr. Busse at the University of Wisconsin Hospital, K4/910 CSC–9988, 600 Highland Ave., Madison, WI 53792, or at wwb@medicine.wisc.edu.
References
This article has been cited by other articles:
Torii, Y., Ito, T., Amakawa, R., Sugimoto, H., Amuro, H., Tanijiri, T., Katashiba, Y., Ogata, M., Yokoi, T., Fukuhara, S.
(2008). Imidazoquinoline Acts as Immune Adjuvant for Functional Alteration of Thymic Stromal Lymphopoietin-Mediated Allergic T Cell Response. J. Immunol.
181: 5340-5349
[Abstract][Full Text]
Yokoi, T., Amakawa, R., Tanijiri, T., Sugimoto, H., Torii, Y., Amuro, H., Son, Y., Tajima, K., Liu, Y.-J., Ito, T., Fukuhara, S.
(2008). Mycobacterium bovis Bacillus Calmette-Guerin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells. Int Immunol
20: 1321-1329
[Abstract][Full Text]
Gilchrist, M., Henderson, W. R. Jr., Clark, A. E., Simmons, R. M., Ye, X., Smith, K. D., Aderem, A.
(2008). Activating transcription factor 3 is a negative regulator of allergic pulmonary inflammation. J. Exp. Med.
205: 2349-2357
[Abstract][Full Text]
Walker, H. A., Chim, L., Chen, E.
(2008). The Role of Asthma Management Beliefs and Behaviors in Childhood Asthma Immune and Clinical Outcomes. J Pediatr Psychol
0: jsn084v1-jsn084
[Abstract][Full Text]
Miyahara, N., Ohnishi, H., Matsuda, H., Miyahara, S., Takeda, K., Koya, T., Matsubara, S., Okamoto, M., Dakhama, A., Haribabu, B., Gelfand, E. W.
(2008). Leukotriene B4 Receptor 1 Expression on Dendritic Cells Is Required for the Development of Th2 Responses and Allergen-Induced Airway Hyperresponsiveness. J. Immunol.
181: 1170-1178
[Abstract][Full Text]
Zhang, G., Lin, R.-L., Wiggers, M. E., Lee, L.-Y.
(2008). Sensitizing effects of chronic exposure and acute inhalation of ovalbumin aerosol on pulmonary C fibers in rats. J. Appl. Physiol.
105: 128-138
[Abstract][Full Text]
Rydell-Tormanen, K., Johnson, J. R., Fattouh, R., Jordana, M., Erjefalt, J. S.
(2008). Induction of Vascular Remodeling in the Lung by Chronic House Dust Mite Exposure. Am. J. Respir. Cell Mol. Bio.
39: 61-67
[Abstract][Full Text]
Simoes, D. C. M., Vassilakopoulos, T., Toumpanakis, D., Petrochilou, K., Roussos, C., Papapetropoulos, A.
(2008). Angiopoietin-1 Protects against Airway Inflammation and Hyperreactivity in Asthma. Am. J. Respir. Crit. Care Med.
177: 1314-1321
[Abstract][Full Text]
Hung, C-H., Chu, Y-T., Hua, Y-M., Hsu, S-H., Lin, C-S., Chang, H-C., Lee, M-S., Jong, Y-J.
(2008). Effects of formoterol and salmeterol on the production of Th1- and Th2-related chemokines by monocytes and bronchial epithelial cells. Eur Respir J
31: 1313-1321
[Abstract][Full Text]
Suzuki, T., Arakawa, H., Mizuno, T., Muramatsu, K., Tadaki, H., Takizawa, T., Mochizuki, H., Tokuyama, K., Matsukura, S., Morikawa, A.
(2008). Differential Regulation of Eotaxin Expression by Dexamethasone in Normal Human Lung Fibroblasts. Am. J. Respir. Cell Mol. Bio.
38: 707-714
[Abstract][Full Text]
Robinson, A. J., Kashanin, D., O'Dowd, F., Williams, V., Walsh, G. M.
(2008). Montelukast inhibition of resting and GM-CSF-stimulated eosinophil adhesion to VCAM-1 under flow conditions appears independent of cysLT1R antagonism. J. Leukoc. Biol.
83: 1522-1529
[Abstract][Full Text]
Johansson, M. W., Kelly, E. A. B., Busse, W. W., Jarjour, N. N., Mosher, D. F.
(2008). Up-Regulation and Activation of Eosinophil Integrins in Blood and Airway after Segmental Lung Antigen Challenge. J. Immunol.
180: 7622-7635
[Abstract][Full Text]
Mishra, N. C., Rir-sima-ah, J., Langley, R. J., Singh, S. P., Pena-Philippides, J. C., Koga, T., Razani-Boroujerdi, S., Hutt, J., Campen, M., Kim, K. C., Tesfaigzi, Y., Sopori, M. L.
(2008). Nicotine Primarily Suppresses Lung Th2 but Not Goblet Cell and Muscle Cell Responses to Allergens. J. Immunol.
180: 7655-7663
[Abstract][Full Text]
Kurth, T, Barr, R G, Gaziano, J M, Buring, J E
(2008). Randomised aspirin assignment and risk of adult-onset asthma in the Women's Health Study. Thorax
63: 514-518
[Abstract][Full Text]
Ponnoth, D. S., Nadeem, A., Mustafa, S. J.
(2008). Adenosine-mediated alteration of vascular reactivity and inflammation in a murine model of asthma. Am. J. Physiol. Heart Circ. Physiol.
294: H2158-H2165
[Abstract][Full Text]
Reuter, S., Heinz, A., Sieren, M., Wiewrodt, R., Gelfand, E. W., Stassen, M., Buhl, R., Taube, C.
(2008). Mast cell-derived tumour necrosis factor is essential for allergic airway disease. Eur Respir J
31: 773-782
[Abstract][Full Text]
Simeone-Penney, M. C., Severgnini, M., Rozo, L., Takahashi, S., Cochran, B. H., Simon, A. R.
(2008). PDGF-induced human airway smooth muscle cell proliferation requires STAT3 and the small GTPase Rac1. Am. J. Physiol. Lung Cell. Mol. Physiol.
294: L698-L704
[Abstract][Full Text]
Fattouh, R., Midence, N. G., Arias, K., Johnson, J. R., Walker, T. D., Goncharova, S., Souza, K. P., Gregory, R. C. Jr., Lonning, S., Gauldie, J., Jordana, M.
(2008). Transforming Growth Factor-{beta} Regulates House Dust Mite-induced Allergic Airway Inflammation but Not Airway Remodeling. Am. J. Respir. Crit. Care Med.
177: 593-603
[Abstract][Full Text]
Nassau, J. H., Tien, K., Fritz, G. K.
(2008). Review of the Literature: Integrating Psychoneuroimmunology into Pediatric Chronic Illness Interventions. J Pediatr Psychol
33: 195-207
[Abstract][Full Text]
Novershtern, N., Itzhaki, Z., Manor, O., Friedman, N., Kaminski, N.
(2008). A Functional and Regulatory Map of Asthma. Am. J. Respir. Cell Mol. Bio.
38: 324-336
[Abstract][Full Text]
Cutz, E., Chiasson, D., Kiren, V., Barbi, E., Ventura, A., Filippone, M., Baraldi, E.
(2008). Chemotherapy plus involved-field radiation in early-stage Hodgkin's disease.. NEJM
358: 743-743
[Full Text]
Schade, J., Stephan, M., Schmiedl, A., Wagner, L., Niestroj, A. J., Demuth, H.-U., Frerker, N., Klemann, C., Raber, K. A., Pabst, R., von Horsten, S.
(2008). Regulation of Expression and Function of Dipeptidyl Peptidase 4 (DP4), DP8/9, and DP10 in Allergic Responses of the Lung in Rats. J. Histochem. Cytochem.
56: 147-155
[Abstract][Full Text]
Masini, E., Giannini, L., Nistri, S., Cinci, L., Mastroianni, R., Xu, W., Comhair, S. A. A., Li, D., Cuzzocrea, S., Matuschak, G. M., Salvemini, D.
(2008). Ceramide: a Key Signaling Molecule in a Guinea Pig Model of Allergic Asthmatic Response and Airway Inflammation. J. Pharmacol. Exp. Ther.
324: 548-557
[Abstract][Full Text]
Mathur, S. K., Schwantes, E. A., Jarjour, N. N., Busse, W. W.
(2008). Age-Related Changes in Eosinophil Function in Human Subjects. Chest
133: 412-419
[Abstract][Full Text]
Ashino, S., Wakita, D., Zhang, Y., Chamoto, K., Kitamura, H., Nishimura, T.
(2008). CpG-ODN inhibits airway inflammation at effector phase through down-regulation of antigen-specific Th2-cell migration into lung. Int Immunol
20: 259-266
[Abstract][Full Text]
Levy, J. H., Adkinson, N. F. Jr
(2008). Anaphylaxis During Cardiac Surgery: Implications for Clinicians. Anesth. Analg.
106: 392-403
[Abstract][Full Text]
Guedes, A. G. P., Jude, J. A., Paulin, J., Kita, H., Lund, F. E., Kannan, M. S.
(2008). Role of CD38 in TNF-{alpha}-induced airway hyperresponsiveness. Am. J. Physiol. Lung Cell. Mol. Physiol.
294: L290-L299
[Abstract][Full Text]
Barthel, S. R., Johansson, M. W., McNamee, D. M., Mosher, D. F.
(2008). Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma. J. Leukoc. Biol.
83: 1-12
[Abstract][Full Text]
Trian, T., Benard, G., Begueret, H., Rossignol, R., Girodet, P.-O., Ghosh, D., Ousova, O., Vernejoux, J.-M., Marthan, R., Tunon-de-Lara, J.-M., Berger, P.
(2007). Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma. J. Exp. Med.
204: 3173-3181
[Abstract][Full Text]
Norris, H. H., Peterson, M. E., Stebbins, C. C., McConchie, B. W., Bundoc, V. G., Trivedi, S., Hodges, M. G., Anthony, R. M., Urban, J. F. Jr, Long, E. O., Keane-Myers, A. M.
(2007). Inhibitory receptor gp49B regulates eosinophil infiltration during allergic inflammation. J. Leukoc. Biol.
82: 1531-1541
[Abstract][Full Text]
Wang, H.-B., Ghiran, I., Matthaei, K., Weller, P. F.
(2007). Airway Eosinophils: Allergic Inflammation Recruited Professional Antigen-Presenting Cells. J. Immunol.
179: 7585-7592
[Abstract][Full Text]
Levy, B. D., Lukacs, N. W., Berlin, A. A., Schmidt, B., Guilford, W. J., Serhan, C. N., Parkinson, J. F.
(2007). Lipoxin A4 stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism. FASEB J.
21: 3877-3884
[Abstract][Full Text]
Haworth, O., Levy, B. D.
(2007). Endogenous lipid mediators in the resolution of airway inflammation. Eur Respir J
30: 980-992
[Abstract][Full Text]
Asano, T., Kobayashi, Y., Ohno, M., Nakayama, T., Kuroda, N., Komuro, I.
(2007). Multivessel Coronary Artery Spasm Refractory to Intensive Medical Treatment. ANGIOLOGY
58: 636-639
[Abstract]
Chen, E., Chim, L. S., Strunk, R. C., Miller, G. E.
(2007). The Role of the Social Environment in Children and Adolescents with Asthma. Am. J. Respir. Crit. Care Med.
176: 644-649
[Abstract][Full Text]
Hayashi, N., Yoshimoto, T., Izuhara, K., Matsui, K., Tanaka, T., Nakanishi, K.
(2007). T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-{gamma} and IL-13 production. Proc. Natl. Acad. Sci. USA
104: 14765-14770
[Abstract][Full Text]
Kwon, Y.-J., Genovesio, A., Youl Kim, N., Hi Chul Kim, , Jung, S., David-Watine, B., Nehrbass, U., Emans, N.
(2007). High-Content Classification of Nucleocytoplasmic Import or Export Inhibitors. J Biomol Screen
12: 621-627
[Abstract]
Jeong, H. C., Lee, S. Y., Lee, E. J., Jung, K. H., Kang, E. H., Lee, S. Y., Kim, J. H., Park, E. K., Lee, S. H., Uhm, C. S., Cho, Y., Shin, C., Shim, J. J., Kim, H. K., In, K. H., Kang, K. H., Yoo, S. H.
(2007). Proteomic Analysis of Peripheral T-Lymphocytes in Patients With Asthma. Chest
132: 489-496
[Abstract][Full Text]
Mishra, A., Wang, M., Schlotman, J., Nikolaidis, N. M., DeBrosse, C. W., Karow, M. L., Rothenberg, M. E.
(2007). Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung. Am. J. Physiol. Lung Cell. Mol. Physiol.
293: L305-L313
[Abstract][Full Text]
Maneechotesuwan, K., Essilfie-Quaye, S., Kharitonov, S. A., Adcock, I. M., Barnes, P. J.
(2007). Loss of Control of Asthma Following Inhaled Corticosteroid Withdrawal Is Associated With Increased Sputum Interleukin-8 and Neutrophils. Chest
132: 98-105
[Abstract][Full Text]
Katoh, S., Ishii, N., Nobumoto, A., Takeshita, K., Dai, S.-Y., Shinonaga, R., Niki, T., Nishi, N., Tominaga, A., Yamauchi, A., Hirashima, M.
(2007). Galectin-9 Inhibits CD44-Hyaluronan Interaction and Suppresses a Murine Model of Allergic Asthma. Am. J. Respir. Crit. Care Med.
176: 27-35
[Abstract][Full Text]
Iwamura, C., Kimura, M. Y., Shinoda, K., Endo, Y., Hasegawa, A., Yamashita, M., Nakayama, T.
(2007). Schnurri-2 regulates Th2-dependent airway inflammation and airway hyperresponsiveness. Int Immunol
19: 755-762
[Abstract][Full Text]
Nadeem, A., Fan, M., Ansari, H. R., Ledent, C., Jamal Mustafa, S.
(2007). Enhanced airway reactivity and inflammation in A2A adenosine receptor-deficient allergic mice. Am. J. Physiol. Lung Cell. Mol. Physiol.
292: L1335-L1344
[Abstract][Full Text]
Simeone-Penney, M. C., Severgnini, M., Tu, P., Homer, R. J., Mariani, T. J., Cohn, L., Simon, A. R.
(2007). Airway Epithelial STAT3 Is Required for Allergic Inflammation in a Murine Model of Asthma. J. Immunol.
178: 6191-6199
[Abstract][Full Text]
Munitz, A., Bachelet, I., Finkelman, F. D., Rothenberg, M. E., Levi-Schaffer, F.
(2007). CD48 Is Critically Involved in Allergic Eosinophilic Airway Inflammation. Am. J. Respir. Crit. Care Med.
175: 911-918
[Abstract][Full Text]
Ramadas, R. A., Sadeghnejad, A., Karmaus, W., Arshad, S. H., Matthews, S., Huebner, M., Kim, D-Y., Ewart, S. L.
(2007). Interleukin-1R antagonist gene and pre-natal smoke exposure are associated with childhood asthma. Eur Respir J
29: 502-508
[Abstract][Full Text]
Matsubara, S., Takeda, K., Kodama, T., Joetham, A., Miyahara, N., Koya, T., Swasey, C. H., Okamoto, M., Dakhama, A., Gelfand, E. W.
(2007). IL-2 and IL-18 Attenuation of Airway Hyperresponsiveness Requires STAT4, IFN-{gamma}, and Natural Killer Cells. Am. J. Respir. Cell Mol. Bio.
36: 324-332
[Abstract][Full Text]
Mustafa, S. J., Nadeem, A., Fan, M., Zhong, H., Belardinelli, L., Zeng, D.
(2007). Effect of a Specific and Selective A2B Adenosine Receptor Antagonist on Adenosine Agonist AMP and Allergen-Induced Airway Responsiveness and Cellular Influx in a Mouse Model of Asthma. J. Pharmacol. Exp. Ther.
320: 1246-1251
[Abstract][Full Text]
Beaty, S. R., Rose, C. E. Jr., Sung, S.-s. J.
(2007). Diverse and Potent Chemokine Production by Lung CD11bhigh Dendritic Cells in Homeostasis and in Allergic Lung Inflammation. J. Immunol.
178: 1882-1895
[Abstract][Full Text]
Hansel, N. N., Diette, G. B.
(2007). Gene Expression Profiling in Human Asthma. Proc Am Thorac Soc
4: 32-36
[Abstract][Full Text]
Levy, B. D., Kohli, P., Gotlinger, K., Haworth, O., Hong, S., Kazani, S., Israel, E., Haley, K. J., Serhan, C. N.
(2007). Protectin D1 Is Generated in Asthma and Dampens Airway Inflammation and Hyperresponsiveness. J. Immunol.
178: 496-502
[Abstract][Full Text]
Korpi-Steiner, N. L., Bates, M. E., Lee, W.-M., Hall, D. J., Bertics, P. J.
(2006). Human rhinovirus induces robust IP-10 release by monocytic cells, which is independent of viral replication but linked to type I interferon receptor ligation and STAT1 activation. J. Leukoc. Biol.
80: 1364-1374
[Abstract][Full Text]
Strickland, D. H., Stumbles, P. A., Zosky, G. R., Subrata, L. S., Thomas, J. A., Turner, D. J., Sly, P. D., Holt, P. G.
(2006). Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells. J. Exp. Med.
203: 2649-2660
[Abstract][Full Text]
Mustapha, O., Datta, R., Oumouna-Benachour, K., Suzuki, Y., Hans, C., Matthews, K., Fallon, K., Boulares, H.
(2006). Poly(ADP-ribose) Polymerase-1 Inhibition Prevents Eosinophil Recruitment by Modulating Th2 Cytokines in a Murine Model of Allergic Airway Inflammation: A Potential Specific Effect on IL-5. J. Immunol.
177: 6489-6496
[Abstract][Full Text]
Szema, A. M., Hamidi, S. A., Lyubsky, S., Dickman, K. G., Mathew, S., Abdel-Razek, T., Chen, J. J., Waschek, J. A., Said, S. I.
(2006). Mice lacking the VIP gene show airway hyperresponsiveness and airway inflammation, partially reversible by VIP. Am. J. Physiol. Lung Cell. Mol. Physiol.
291: L880-L886
[Abstract][Full Text]
Hellings, P. W., Kasran, A., Bullens, D., Overbergh, L., Mathieu, C., Heremans, H., Matthys, P., Boon, L., Jorissen, M., Ceuppens, J. L.
(2006). IL-10- and IL-12-Independent Down-Regulation of Allergic Sensitization by Stimulation of CD40 Signaling. J. Immunol.
177: 5138-5144
[Abstract][Full Text]
Tschopp, C. M., Spiegl, N., Didichenko, S., Lutmann, W., Julius, P., Virchow, J. C., Hack, C. E., Dahinden, C. A.
(2006). Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma. Blood
108: 2290-2299
[Abstract][Full Text]
Huston, D. P.
(2006). Update in allergy and immunology.. ANN INTERN MED
145: 454-458
[Full Text]
Muller, M., Grunewald, J., Olgart Hoglund, C., Dahlen, B., Eklund, A., Stridh, H.
(2006). Altered apoptosis in bronchoalveolar lavage lymphocytes after allergen exposure of atopic asthmatic subjects. Eur Respir J
28: 513-522
[Abstract][Full Text]
Gounni, A. S.
(2006). The high-affinity IgE receptor (Fc{epsilon}RI): a critical regulator of airway smooth muscle cells?. Am. J. Physiol. Lung Cell. Mol. Physiol.
291: L312-L321
[Abstract][Full Text]
Korf, J. E., Pynaert, G., Tournoy, K., Boonefaes, T., Van Oosterhout, A., Ginneberge, D., Haegeman, A., Verschoor, J. A., De Baetselier, P., Grooten, J.
(2006). Macrophage Reprogramming by Mycolic Acid Promotes a Tolerogenic Response in Experimental Asthma. Am. J. Respir. Crit. Care Med.
174: 152-160
[Abstract][Full Text]
Shahabuddin, S., Ji, R., Wang, P., Brailoiu, E., Dun, N., Yang, Y., Aksoy, M. O., Kelsen, S. G.
(2006). CXCR3 chemokine receptor-induced chemotaxis in human airway epithelial cells: role of p38 MAPK and PI3K signaling pathways. Am. J. Physiol. Cell Physiol.
291: C34-C39
[Abstract][Full Text]
Canonica, G. W.
(2006). Treating Asthma as an Inflammatory Disease. Chest
130: 21S-28S
[Abstract][Full Text]
Sigurdarson, S. T., Kline, J. N.
(2006). School Proximity to Concentrated Animal Feeding Operations and Prevalence of Asthma in Students. Chest
129: 1486-1491
[Abstract][Full Text]
Ishikawa, Y., Yoshimoto, T., Nakanishi, K.
(2006). Contribution of IL-18-induced innate T cell activation to airway inflammation with mucus hypersecretion and airway hyperresponsiveness. Int Immunol
18: 847-855
[Abstract][Full Text]
Griffin, M. J., Chen, E.
(2006). Perceived Control and Immune and Pulmonary Outcomes in Children With Asthma. Psychosom. Med.
68: 493-499
[Abstract][Full Text]
Moisan, J., Camateros, P., Thuraisingam, T., Marion, D., Koohsari, H., Martin, P., Boghdady, M. L., Ding, A., Gaestel, M., Guiot, M. C., Martin, J. G., Radzioch, D.
(2006). TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway. Am. J. Physiol. Lung Cell. Mol. Physiol.
290: L987-L995
[Abstract][Full Text]
Miller, G. E., Chen, E.
(2006). Life stress and diminished expression of genes encoding glucocorticoid receptor and beta2-adrenergic receptor in children with asthma. Proc. Natl. Acad. Sci. USA
103: 5496-5501
[Abstract][Full Text]
Matsubara, S., Koya, T., Takeda, K., Joetham, A., Miyahara, N., Pine, P., Masuda, E. S., Swasey, C. H., Gelfand, E. W.
(2006). Syk Activation in Dendritic Cells Is Essential for Airway Hyperresponsiveness and Inflammation. Am. J. Respir. Cell Mol. Bio.
34: 426-433
[Abstract][Full Text]
Fritz, D. K., Kerr, C., Tong, L., Smyth, D., Richards, C. D.
(2006). Oncostatin-M Up-Regulates VCAM-1 and Synergizes with IL-4 in Eotaxin Expression: Involvement of STAT6. J. Immunol.
176: 4352-4360
[Abstract][Full Text]
Akbari, O., Faul, J. L., Hoyte, E. G., Berry, G. J., Wahlstrom, J., Kronenberg, M., DeKruyff, R. H., Umetsu, D. T.
(2006). CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma.. NEJM
354: 1117-1129
[Abstract][Full Text]
Lee, K. S., Lee, H. K., Hayflick, J. S., Lee, Y. C., Puri, K. D.
(2006). Inhibition of phosphoinositide 3-kinase {delta} attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model. FASEB J.
20: 455-465
[Abstract][Full Text]
Taube, C., Miyahara, N., Ott, V., Swanson, B., Takeda, K., Loader, J., Shultz, L. D., Tager, A. M., Luster, A. D., Dakhama, A., Gelfand, E. W.
(2006). The Leukotriene B4 Receptor (BLT1) Is Required for Effector CD8+ T Cell-Mediated, Mast Cell-Dependent Airway Hyperresponsiveness.. J. Immunol.
176: 3157-3164
[Abstract][Full Text]
Truyen, E, Coteur, L, Dilissen, E, Overbergh, L, Dupont, L J, Ceuppens, J L, Bullens, D M A
(2006). Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients. Thorax
61: 202-208
[Abstract][Full Text]
Erzurum, S. C.
(2006). Inhibition of Tumor Necrosis Factor {alpha} for Refractory Asthma. NEJM
354: 754-758
[Full Text]
Lopez, E., del Pozo, V., Miguel, T., Sastre, B., Seoane, C., Civantos, E., Llanes, E., Baeza, M. L., Palomino, P., Cardaba, B., Gallardo, S., Manzarbeitia, F., Zubeldia, J. M., Lahoz, C.
(2006). Inhibition of Chronic Airway Inflammation and Remodeling by Galectin-3 Gene Therapy in a Murine Model. J. Immunol.
176: 1943-1950
[Abstract][Full Text]
Matsubara, S., Li, G., Takeda, K., Loader, J. E., Pine, P., Masuda, E. S., Miyahara, N., Miyahara, S., Lucas, J. J., Dakhama, A., Gelfand, E. W.
(2006). Inhibition of Spleen Tyrosine Kinase Prevents Mast Cell Activation and Airway Hyperresponsiveness. Am. J. Respir. Crit. Care Med.
173: 56-63
[Abstract][Full Text]
Koya, T., Kodama, T., Takeda, K., Miyahara, N., Yang, E.-S., Taube, C., Joetham, A., Park, J.-W., Dakhama, A., Gelfand, E. W.
(2006). Importance of Myeloid Dendritic Cells in Persistent Airway Disease after Repeated Allergen Exposure. Am. J. Respir. Crit. Care Med.
173: 42-55
[Abstract][Full Text]
Medoff, B. D., Tager, A. M., Jackobek, R., Means, T. K., Wang, L., Luster, A. D.
(2006). Antibody-antigen interaction in the airway drives early granulocyte recruitment through BLT1. Am. J. Physiol. Lung Cell. Mol. Physiol.
290: L170-L178
[Abstract][Full Text]
Georas, S. N., Guo, J., De Fanis, U., Casolaro, V.
(2005). T-helper cell type-2 regulation in allergic disease. Eur Respir J
26: 1119-1137
[Abstract][Full Text]
Aurora, A. B., Baluk, P., Zhang, D., Sidhu, S. S., Dolganov, G. M., Basbaum, C., McDonald, D. M., Killeen, N.
(2005). Immune Complex-Dependent Remodeling of the Airway Vasculature in Response to a Chronic Bacterial Infection. J. Immunol.
175: 6319-6326
[Abstract][Full Text]
Woszczek, G., Pawliczak, R., Qi, H.-Y., Nagineni, S., Alsaaty, S., Logun, C., Shelhamer, J. H.
(2005). Functional Characterization of Human Cysteinyl Leukotriene 1 Receptor Gene Structure. J. Immunol.
175: 5152-5159
[Abstract][Full Text]
Mizue, Y., Ghani, S., Leng, L., McDonald, C., Kong, P., Baugh, J., Lane, S. J., Craft, J., Nishihira, J., Donnelly, S. C., Zhu, Z., Bucala, R.
(2005). Role for macrophage migration inhibitory factor in asthma. Proc. Natl. Acad. Sci. USA
102: 14410-14415
[Abstract][Full Text]
Desmet, C., Gosset, P., Henry, E., Garze, V., Faisca, P., Vos, N., Jaspar, F., Melotte, D., Lambrecht, B., Desmecht, D., Pajak, B., Moser, M., Lekeux, P., Bureau, F.
(2005). Treatment of Experimental Asthma by Decoy-mediated Local Inhibition of Activator Protein-1. Am. J. Respir. Crit. Care Med.
172: 671-678
[Abstract][Full Text]
Vermaelen, K., Pauwels, R.
(2005). Pulmonary Dendritic Cells. Am. J. Respir. Crit. Care Med.
172: 530-551
[Abstract][Full Text]
Beavitt, S.-J. E., Harder, K. W., Kemp, J. M., Jones, J., Quilici, C., Casagranda, F., Lam, E., Turner, D., Brennan, S., Sly, P. D., Tarlinton, D. M., Anderson, G. P., Hibbs, M. L.
(2005). Lyn-Deficient Mice Develop Severe, Persistent Asthma: Lyn Is a Critical Negative Regulator of Th2 Immunity. J. Immunol.
175: 1867-1875
[Abstract][Full Text]
Miyahara, N., Takeda, K., Miyahara, S., Matsubara, S., Koya, T., Joetham, A., Krishnan, E., Dakhama, A., Haribabu, B., Gelfand, E. W.
(2005). Requirement for Leukotriene B4 Receptor 1 in Allergen-induced Airway Hyperresponsiveness. Am. J. Respir. Crit. Care Med.
172: 161-167
[Abstract][Full Text]
Ratnawati, R, Thomas, P S
(2005). Exhaled nitric oxide in paediatric asthma. Chronic Respiratory Disease
2: 163-174
[Abstract]
Loewen, M. E., Forsyth, G. W.
(2005). Structure and Function of CLCA Proteins. Physiol. Rev.
85: 1061-1092
[Abstract][Full Text]
Matsuda, H., Suda, T., Sato, J., Nagata, T., Koide, Y., Chida, K., Nakamura, H.
(2005). {alpha}-Galactosylceramide, a Ligand of Natural Killer T Cells, Inhibits Allergic Airway Inflammation. Am. J. Respir. Cell Mol. Bio.
33: 22-31
[Abstract][Full Text]
Joetham, A., Takeda, K., Taube, C., Miyahara, N., Kanehiro, A., Dakhama, A., Gelfand, E. W.
(2005). Airway Hyperresponsiveness in the Absence of CD4+ T Cells after Primary but Not Secondary Challenge. Am. J. Respir. Cell Mol. Bio.
33: 89-96
[Abstract][Full Text]
Knoops, L., Louahed, J., Van Snick, J., Renauld, J.-C.
(2005). IL-9 Promotes but Is Not Necessary for Systemic Anaphylaxis. J. Immunol.
175: 335-341
[Abstract][Full Text]
Previous
