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Previous Volume 344:382-383 February 1, 2001 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: There are several reasons for advocating caution in generalizing the beneficial findings reported by Chan et al. (Oct. 19 issue)¹ to other patients with proliferative lupus glomerulonephritis. First, mycophenolate mofetil was compared with oral rather than pulsed intravenous cyclophosphamide, which has become the standard of treatment for patients with diffuse proliferative lupus nephritis.²

Second, patients with poor prognostic factors with respect to renal outcomes were either not included in the study or were underrepresented.^3,4 In particular, patients with serum creatinine concentrations of more than 3.4 mg per deciliter (300 µmol per liter) were excluded, and many had . . . [Full Text of this Article]

References

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• Gottlieb, B. S., Ilowite, N. T. (2006). Systemic Lupus Erythematosus in Children and Adolescents.. Pediatr. Rev. 27: 323-330 [Full Text]  
• Birck, R., Newman, M., Braun, C., Neumann, I., Nemoto, K., Yard, B., Waldherr, R., van der Woude, F. J. (2006). 15-Deoxyspergualin and cyclophosphamide, but not mycophenolate mofetil, prolong survival and attenuate renal disease in a murine model of ANCA-associated crescentic nephritis. Nephrol Dial Transplant 21: 58-63 [Abstract] [Full Text]  
• Karim, M. Y., Alba, P., Cuadrado, M.-J., Abbs, I. C., D'Cruz, D. P., Khamashta, M. A., Hughes, G. R. V. (2002). Mycophenolate mofetil for systemic lupus erythematosus refractory to other immunosuppressive agents. Rheumatology (Oxford) 41: 876-882 [Abstract] [Full Text]