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Multiple-organ failure is one of the most challenging clinical problems in intensive care. This and related conditions, such as the systemic inflammatory response syndrome and the multiple organ dysfunction syndrome, represent the end result of a wide variety of insults, including trauma, sepsis, and poisoning, that lead to extensive tissue injury and, ultimately, organ failure. As the editors point out in their preface, multiple-organ failure is not a disease or even a syndrome but, rather, a concept that attempts to draw together a patchwork of pathologic processes. The goal of this book is to describe the underlying biologic mechanisms that
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