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Previous Volume 344:452-454 February 8, 2001 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Cirrhosis represents a late stage of progressive scarring in chronic liver disease. It begins with subendothelial or pericentral fibrosis (hepatic fibrosis) and progresses to panlobular fibrosis with nodule formation (cirrhosis). Once established, fibrosis has generally been considered to be irreversible. This belief was established more than half a century ago, when the diagnosis of cirrhosis was made clinically on the basis of signs of end-stage liver disease, such as ascites, muscle wasting, variceal bleeding, jaundice, and encephalopathy. These features continue to indicate a poor prognosis in the absence of liver transplantation and are still used to classify the severity of . . . [Full Text of this Article]

References

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• Kiesewetter, C. H, Sheron, N., Vettukattill, J. J, Hacking, N., Stedman, B., Millward-Sadler, H., Haw, M., Cope, R., Salmon, A. P, Sivaprakasam, M. C, Kendall, T., Keeton, B. R, Iredale, J. P, Veldtman, G. R (2007). Hepatic changes in the failing Fontan circulation. Heart 93: 579-584 [Abstract] [Full Text]  
• Kawada, N (2006). Human hepatic stellate cells are resistant to apoptosis: implications for human fibrogenic liver disease.. Gut 55: 1073-1074 [Full Text]  
• Kang, J. S., Morimura, K., Salim, E. I., Wanibuchi, H., Yamaguchi, S., Fukushima, S. (2005). Persistence of Liver Cirrhosis in Association with Proliferation of Nonparenchymal Cells and Altered Location of {alpha}-Smooth Muscle Actin-Positive Cells. Toxicol Pathol 33: 329-335 [Abstract] [Full Text]