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Correspondence
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Volume 344:458-459 February 8, 2001 Number 6
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Polymorphisms in the Factor VII Gene and the Risk of Myocardial Infarction

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To the Editor: Girelli et al. (Sept. 14 issue)1 found that polymorphic alleles of the factor VII gene that are associated with low plasma levels of the coagulation factor confer protection against myocardial infarction in patients with coronary atherosclerosis. The authors discuss why their results differ from those of other investigators. They postulate that differences between the positive studies, all of which were carried out in Italian patients, and the negative ones, which were carried out in populations in France, Northern Ireland, and the Netherlands, might be related to the higher prevalence of the "protective" alleles in southern Europe (prevalence . . . [Full Text of this Article]

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