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Previous Volume 344:673-675 March 1, 2001 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The anticoagulant mechanism of heparin was obscure until 1973,¹ when it was found that heparin enhances by as much as 1000 times the ability of the plasma protein antithrombin to form complexes with thrombin, factor Xa, and factor IXa, thereby inhibiting their activity and acting as an anticoagulant. Three years later, Lam et al. showed that only a small fraction of heparin binds to purified antithrombin, yet this fraction possesses virtually all of the anticoagulant activity of heparin.² The region responsible for the anticoagulant activity of heparin has a unique oligosaccharide structure — the antithrombin-binding domain. Lindahl et al. made . . . [Full Text of this Article]

References

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