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Previous Volume 345:34-40 July 5, 2001 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors' clinical recommendations.

Patient 1 is a 52-year-old woman at average risk for breast cancer and osteoporosis who is having menopause-related hot flashes and disturbed sleep. Patient 2 is a 58-year-old woman with osteopenia whose mother had breast cancer. Patient 3 is a 65-year-old woman with a history of coronary revascularization and documented osteoporosis. Each wants to know whether hormone-replacement therapy is right for her.

The Clinical Problem

Overview

. . . [Full Text of this Article]

The Cardiovascular Disease Conundrum

Strategies and Evidence

Definite Benefits

            Symptoms of Menopause

            Osteoporosis

Definite Risks

            Endometrial Cancer

            Venous Thromboembolism

Probable Increase in Risk

            Breast Cancer

            Gallbladder Disease

Areas of Uncertainty

Coronary Heart Disease

Colorectal Cancer

Cognitive Dysfunction

Ovarian Cancer and Other Disorders

Guidelines

Conclusions and Recommendations

Source Information

From the Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School (J.E.M.), and the Reproductive Endocrine Unit, Massachusetts General Hospital, Harvard Medical School (K.A.M.) — all in Boston.

Address reprint requests to Dr. Manson at the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, 900 Commonwealth Ave. East, Boston, MA 02215, or at jmanson@rics.bwh.harvard.edu.

References

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