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Correspondence
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Volume 345:68-69 July 5, 2001 Number 1
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The Cost Effectiveness of Antiretroviral Therapy for HIV Disease

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To the Editor: The study by Freedberg et al. (March 15 issue)1 compared a three-drug regimen with no antiretroviral therapy in patients infected with the human immunodeficiency virus (HIV) and found the regimen to be effective. One weakness of this study is that no treatment was chosen as the reference category. There were no comparisons between triple therapy and double therapy or between triple therapy and monotherapy. Studies of cost effectiveness should be guided by clinical research, and the controlled studies in the analysis by Freedberg et al. did not include untreated groups. Since withholding treatment is unethical, the design . . . [Full Text of this Article]

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