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Previous Volume 345:740-746 September 6, 2001 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations.

A 56-year-old man with no history of cardiac disease and no cardiac symptoms has a holosystolic murmur at the apex that radiates to the axilla. Echocardiography shows moderate mitral regurgitation with mild left ventricular dilatation. How should this patient's care be managed?

There are about 500,000 discharge diagnoses of mitral-valve disease annually in the United States.¹ However, estimates of the prevalence of . . . [Full Text of this Article]

The Clinical Problem

Causation

Pathophysiological Process

Diagnosis

Echocardiography

Outcome

Strategies and Evidence

Medical Therapy

Mitral-Valve Surgery

Areas of Uncertainty

Assessment of the Severity of Mitral Regurgitation

Medical Therapy for Primary Valve Disease

Timing of Surgical Intervention

Valve Repair in Patients with Secondary Mitral Regurgitation

Guidelines

Conclusions and Recommendations

Source Information

From the Division of Cardiology, University of Washington, Seattle.

References

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