Chemokines and the Molecular Basis of Cancer Metastasis

doi:10.1056/NEJM200109133451113

Volume 345:833-835		September 13, 2001		Number 11

Chemokines and the Molecular Basis of Cancer Metastasis

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Metastasis is the chief cause of morbidity and mortality inmost cancers. Appropriately, the words "cancer" (from the Latinfor "crab") and "metastasis" (from the Greek for "change inposition") both refer to cell movement: the crab-like invasionof cancer into healthy tissue and the migration of cancer cellsto sites distant from the primary tumor. Since the work of Pagetmore than 100 years ago, pathologists have recognized that themovement of cancer cells is not random and that different typesof cancer have different destinations. To explain this specificity,the "soil and seed" theory states that different organs . . . [Full Text of this Article]

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