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Correspondence
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Volume 345:1130-1131 October 11, 2001 Number 15
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Evidence That Human Cardiac Myocytes Divide after Myocardial Infarction

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To the Editor: Beltrami et al. (June 7 issue)1 are to be congratulated for their elegant demonstration that mitosis can occur in the human ventricle. It should be noted, however, that the ability of mammalian cardiac myocytes to divide has been described by many investigators since the end of the 19th century. Rumyantsev, in a 1977 review, stated that "a limited percentage" of adult mammalian ventricular myocytes can overcome the most rigid restraints regarding the resumption of DNA synthesis and "pass through all phases of the mitotic cycle."2 He also noted that the capacity for mitosis is even greater in . . . [Full Text of this Article]

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