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Previous Volume 345:1271-1272 October 25, 2001 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Serious injury causes "a great constitutional disturbance," as Daniel Drake, a surgeon, said in describing his own burn injury in 1830.¹ The disturbance includes an initial "ebb phase" of immediate post-injury hypoperfusion, followed by an intense and often protracted "flow phase" characterized by fever, hyperdynamic circulation, insulin-resistant hyperglycemia, and protein catabolism that persists throughout the period of recovery or until death.² The changes are thought to be driven by some combination of tissue hypoxia, breakdown of the gut barrier, evaporative water loss, and infection. Unfortunately, the biology behind this response, which occurs in most mammals, has proved so complex that . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Sheridan, R. L. (2003). Burn Care: Results of Technical and Organizational Progress. JAMA 290: 719-722 [Full Text]