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Previous Volume 345:1345-1346 November 1, 2001 Number 18 Next

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One hundred years ago, type 2 diabetes mellitus was considered a rare disease, but recently there has been an explosive increase in its incidence. About 16 million Americans have type 2 diabetes,¹ and at least an equal number have impaired glucose tolerance. Insulin resistance and hyperinsulinemia are characteristics of both type 2 diabetes and impaired glucose tolerance. These metabolic derangements, combined with the hypertension and dyslipidemia that are common in type 2 diabetes and impaired glucose tolerance, markedly increase the risk of cardiovascular, peripheral vascular, and cerebrovascular disease.

Why has the incidence of type 2 diabetes increased so rapidly? Considerable . . . [Full Text of this Article]

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• Ruan, X., Zheng, F., Guan, Y. (2008). PPARs and the kidney in metabolic syndrome. Am. J. Physiol. Renal Physiol. 294: F1032-F1047 [Abstract] [Full Text]  
• Adya, R., Tan, B. K., Punn, A., Chen, J., Randeva, H. S. (2008). Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis. Cardiovasc Res 78: 356-365 [Abstract] [Full Text]  
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• Xie, L., Boyle, D., Sanford, D., Scherer, P. E., Pessin, J. E., Mora, S. (2006). Intracellular Trafficking and Secretion of Adiponectin Is Dependent on GGA-coated Vesicles. J. Biol. Chem. 281: 7253-7259 [Abstract] [Full Text]  
• Zeller, M., Steg, P. G., Ravisy, J., Laurent, Y., Janin-Manificat, L., L'Huillier, I., Beer, J.-C., Oudot, A., Rioufol, G., Makki, H., Farnier, M., Rochette, L., Verges, B., Cottin, Y., for the Observatoire des Infarctus de Cote-d'Or Su, (2005). Prevalence and Impact of Metabolic Syndrome on Hospital Outcomes in Acute Myocardial Infarction. Arch Intern Med 165: 1192-1198 [Abstract] [Full Text]  
• Guan, Y. (2004). Peroxisome Proliferator-Activated Receptor Family and Its Relationship to Renal Complications of the Metabolic Syndrome. J. Am. Soc. Nephrol. 15: 2801-2815 [Abstract] [Full Text]  
• Meier, U., Gressner, A. M. (2004). Endocrine Regulation of Energy Metabolism: Review of Pathobiochemical and Clinical Chemical Aspects of Leptin, Ghrelin, Adiponectin, and Resistin. Clin. Chem. 50: 1511-1525 [Abstract] [Full Text]  
• Morales, A., Wasserfall, C., Brusko, T., Carter, C., Schatz, D., Silverstein, J., Ellis, T., Atkinson, M. (2004). Adiponectin and Leptin Concentrations May Aid in Discriminating Disease Forms in Children and Adolescents With Type 1 and Type 2 Diabetes. Diabetes Care 27: 2010-2014 [Abstract] [Full Text]  
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• Verma, S., Li, S.-H., Wang, C.-H., Fedak, P. W.M., Li, R.-K., Weisel, R. D., Mickle, D. A.G. (2003). Resistin Promotes Endothelial Cell Activation: Further Evidence of Adipokine-Endothelial Interaction. Circulation 108: 736-740 [Abstract] [Full Text]  
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• Hertzel, A. V., Bennaars-Eiden, A., Bernlohr, D. A. (2002). Increased lipolysis in transgenic animals overexpressing the epithelial fatty acid binding protein in adipose cells. J. Lipid Res. 43: 2105-2111 [Abstract] [Full Text]  
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