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Case Records of the Massachusetts General Hospital
Weekly Clinicopathological Exercises
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Volume 345:1409-1415 November 8, 2001 Number 19
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Case 34-2001— A 54-Year-Old Woman with Multiple Sclerosis, Prolonged Fever, and Skin Nodules
Joseph O. Jacobson, and Laurence de Leval

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Presentation of Case

A 54-year-old woman was admitted to the hospital with fever of unknown origin of one year's duration.

The patient was confined to a bed because of multiple sclerosis of 20 years' duration. Her fever had initially been ascribed to a urinary tract infection caused by an indwelling catheter, but the fever persisted after successful treatment of the infection. Seven months before the current admission, the white-cell count fell to 1300 per cubic millimeter, and chronic anemia developed. Her customary therapy with interferon beta-1a and interferon beta-1b was discontinued, without defervescence. Five months before admission, skin nodules appeared on the left . . . [Full Text of this Article]

Admission to Another Hospital

Admission to This Hospital

Differential Diagnosis

Panniculitis

Erythema Induratum

Erythema Nodosum

Other Forms of Panniculitis

Other Lymphomas Involving the Subcutis

Clinical Diagnosis

Dr. Joseph O. Jacobson's Diagnosis

Pathological Discussion

Anatomical Diagnosis

References




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