FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Volume 345:1435-1443 November 15, 2001 Number 20 Next

	Full Text PDF Editorial by Jessup, M. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

ABSTRACT

Background Implantable left ventricular assist devices have benefited patients with end-stage heart failure as a bridge to cardiac transplantation, but their long-term use for the purpose of enhancing survival and the quality of life has not been evaluated.

Methods We randomly assigned 129 patients with end-stage heart failure who were ineligible for cardiac transplantation to receive a left ventricular assist device (68 patients) or optimal medical management (61). All patients had symptoms of New York Heart Association class IV heart failure.

Results Kaplan–Meier survival analysis showed a reduction of 48 percent in the risk of death from any cause in the group that received left ventricular assist devices as compared with the medical-therapy group (relative risk, 0.52; 95 percent confidence interval, 0.34 to 0.78; P=0.001). The rates of survival at one year were 52 percent in the device group and 25 percent in the medical-therapy group (P=0.002), and the rates at two years were 23 percent and 8 percent (P=0.09), respectively. The frequency of serious adverse events in the device group was 2.35 (95 percent confidence interval, 1.86 to 2.95) times that in the medical-therapy group, with a predominance of infection, bleeding, and malfunction of the device. The quality of life was significantly improved at one year in the device group.

Conclusions The use of a left ventricular assist device in patients with advanced heart failure resulted in a clinically meaningful survival benefit and an improved quality of life. A left ventricular assist device is an acceptable alternative therapy in selected patients who are not candidates for cardiac transplantation.

Source Information

From the College of Physicians and Surgeons (E.A.R., A.C.G., A.J.M., D.D.A., A.R.T., R.G.L., P.M.), and the Joseph L. Mailman School of Public Health (A.C.G., A.J.M., D.F.H., P.M.), Columbia University, New York; Brigham and Women's Hospital, Boston (L.W.S.); Sharp Memorial Hospital, San Diego, Calif. (W.D.); LDS Hospital, Salt Lake City (J.W.L.); and the National Heart, Lung, and Blood Institute, Bethesda, Md. (J.T.W.).

Other authors were Nuala S. Ronan, R.N., Peter A. Shapiro, M.D., and Ronald M. Lazar, Ph.D. (College of Physicians and Surgeons, Columbia University, New York); Leslie W. Miller, M.D. (University of Minnesota, Minneapolis); Lopa Gupta, R.D., M.P.H. (College of Physicians and Surgeons, Columbia University, New York); O. Howard Frazier, M.D. (Texas Heart Institute, Houston); Patrice Desvigne-Nickens, M.D. (National Heart, Lung, and Blood Institute, Bethesda, Md.); Mehmet C. Oz, M.D. (College of Physicians and Surgeons, Columbia University, New York); and Victor L. Poirier, M.B.A. (Thoratec Corporation, Pleasanton, Calif.).

Address reprint requests to the International Center for Health Outcomes and Innovation Research, Columbia University, 600 W. 168th St., 7th Fl., New York, NY 10032.

Full Text of this Article

This article has been cited by other articles:

• Allen, L. A., Yager, J. E., Funk, M. J., Levy, W. C., Tulsky, J. A., Bowers, M. T., Dodson, G. C., O'Connor, C. M., Felker, G. M. (2008). Discordance Between Patient-Predicted and Model-Predicted Life Expectancy Among Ambulatory Patients With Heart Failure. JAMA 299: 2533-2542 [Abstract] [Full Text]  
• Long, J. W., Healy, A. H., Rasmusson, B. Y., Cowley, C. G., Nelson, K. E., Kfoury, A. G., Clayson, S. E., Reid, B. B., Moore, S. A., Blank, D. U., Renlund, D. G. (2008). Improving outcomes with long-term "destination" therapy using left ventricular assist devices.. J. Thorac. Cardiovasc. Surg. 135: 1353-1361 [Abstract] [Full Text]  
• Braunwald, E. (2008). The Management of Heart Failure: The Past, the Present, and the Future. Circ Heart Fail 1: 58-62 [Full Text]  
• Gregoric, I. D., Bruckner, B. A., Jacob, L., Kar, B., Cohn, W. E., La Francesca, S., Frazier, O.H. (2008). Clinical Experience With Sternotomy Versus Subcostal Approach for Exchange of the HeartMate XVE to the HeartMate II Ventricular Assist Device.. Ann. Thorac. Surg. 85: 1646-1649 [Abstract] [Full Text]  
• Kartha, V., Gomez, W., Wu, B., Tremper, K. (2008). Laparoscopic cholecystectomy in a patient with an implantable left ventricular assist device. Br J Anaesth 100: 652-655 [Abstract] [Full Text]  
• Takeda, K., Matsumiya, G., Matsue, H., Sakaki, M., Sakaguchi, T., Fujita, T., Sawa, Y. (2008). Left Ventricular Reconstructive Surgery in Ischemic Dilated Cardiomyopathy Complicated With Cardiogenic Shock. Ann. Thorac. Surg. 85: 1339-1343 [Abstract] [Full Text]  
• Soppa, G. K.R., Lee, J., Stagg, M. A., Felkin, L. E., Barton, P. J.R., Siedlecka, U., Youssef, S., Yacoub, M. H., Terracciano, C. M.N. (2008). Role and possible mechanisms of clenbuterol in enhancing reverse remodelling during mechanical unloading in murine heart failure. Cardiovasc Res 77: 695-706 [Abstract] [Full Text]  
• Bullard, T. A., Protack, T. L., Aguilar, F., Bagwe, S., Massey, H. T., Blaxall, B. C. (2008). Identification of Nogo as a novel indicator of heart failure. Physiol. Genomics 32: 182-189 [Abstract] [Full Text]  
• Padera, R. F. Jr., Schoen, F. J. (2008). Pathology of Cardiac Surgery. Card Surg Adult 3: 111-178 [Full Text]  
• Nwakanma, L. U., Shah, A. S., Conte, J. V., Baumgartner, W. A. (2008). Heart Transplantation. Card Surg Adult 3: 1539-1578 [Full Text]  
• Aggarwal, S., Cheema, F., Oz, M. C., Naka, Y. (2008). Long-Term Mechanical Circulatory Support. Card Surg Adult 3: 1609-1628 [Full Text]  
• Frazier, O.H., Myers, T. J., Gregoric, I. (2008). Total Artificial Heart. Card Surg Adult 3: 1629-1638 [Full Text]  
• Kooshkabadi, M., Kalogeropoulos, A., Babaliaros, V. C., Lerakis, S. (2008). Transesophageal guided left atrial positioning of a percutaneous ventricular assist device. Eur J Echocardiogr 9: 175-177 [Abstract] [Full Text]  
• Jeger, R. V., Lowe, A. M., Buller, C. E., Pfisterer, M. E., Dzavik, V., Webb, J. G., Hochman, J. S., Jorde, U. P., for the SHOCK Investigators, (2007). Hemodynamic Parameters Are Prognostically Important in Cardiogenic Shock But Similar Following Early Revascularization or Initial Medical Stabilization: A Report From the SHOCK Trial. Chest 132: 1794-1803 [Abstract] [Full Text]  
• Esmore, D., Spratt, P., Larbalestier, R., Tsui, S., Fiane, A., Ruygrok, P., Meyers, D., Woodard, J. (2007). VentrAssistTM left ventricular assist device: clinical trial results and Clinical Development Plan update. Eur. J. Cardiothorac. Surg. 32: 735-744 [Abstract] [Full Text]  
• Haft, J., Armstrong, W., Dyke, D. B., Aaronson, K. D., Koelling, T. M., Farrar, D. J., Pagani, F. D. (2007). Hemodynamic and Exercise Performance With Pulsatile and Continuous-Flow Left Ventricular Assist Devices. Circulation 116: I-8-I-15 [Abstract] [Full Text]  
• Mau, J., Menzie, S., Ward, M., Bundgaard, H., Hunyor, S. (2007). Time-dependent response of both ventricles after septal ablation: Implications for biventricular support after left ventricular assist device placement. J. Thorac. Cardiovasc. Surg. 134: 579-586 [Abstract] [Full Text]  
• Stone, M. E. (2007). Current Status of Mechanical Circulatory Assistance. SEMIN CARDIOTHORAC VASC ANESTH 11: 185-204 [Abstract]  
• Chumnanvej, S., Wood, M. J., MacGillivray, T. E., Melo, M. F. V. (2007). Perioperative Echocardiographic Examination for Ventricular Assist Device Implantation. Anesth. Analg. 105: 583-601 [Abstract] [Full Text]  
• Miller, L. W., Pagani, F. D., Russell, S. D., John, R., Boyle, A. J., Aaronson, K. D., Conte, J. V., Naka, Y., Mancini, D., Delgado, R. M., MacGillivray, T. E., Farrar, D. J., Frazier, O.H., the HeartMate II Clinical Investigators, (2007). Use of a Continuous-Flow Device in Patients Awaiting Heart Transplantation. NEJM 357: 885-896 [Abstract] [Full Text]  
• Rogers, J. G., Butler, J., Lansman, S. L., Gass, A., Portner, P. M., Pasque, M. K., Pierson, R. N. III, for the INTrEPID Investigators, (2007). Chronic Mechanical Circulatory Support for Inotrope-Dependent Heart Failure Patients Who Are Not Transplant Candidates: Results of the INTrEPID Trial. J Am Coll Cardiol 50: 741-747 [Abstract] [Full Text]  
• Stevenson, L. W., Couper, G. (2007). On the Fledgling Field of Mechanical Circulatory Support. J Am Coll Cardiol 50: 748-751 [Full Text]  
• Zierer, A., Melby, S. J., Voeller, R. K., Guthrie, T. J., Ewald, G. A., Shelton, K., Pasque, M. K., Moon, M. R., Damiano, R. J. Jr, Moazami, N. (2007). Late-Onset Driveline Infections: The Achilles' Heel of Prolonged Left Ventricular Assist Device Support. Ann. Thorac. Surg. 84: 515-520 [Abstract] [Full Text]  
• John, R., Liao, K., Lietz, K., Kamdar, F., Colvin-Adams, M., Boyle, A., Miller, L., Joyce, L. (2007). Experience with the Levitronix CentriMag circulatory support system as a bridge to decision in patients with refractory acute cardiogenic shock and multisystem organ failure. J. Thorac. Cardiovasc. Surg. 134: 351-358 [Abstract] [Full Text]  
• Kirkpatrick, J. N., Vannan, M. A., Narula, J., Lang, R. M. (2007). Echocardiography in Heart Failure: Applications, Utility, and New Horizons. J Am Coll Cardiol 50: 381-396 [Abstract] [Full Text]  
• Hunt, S. A. (2007). Mechanical Circulatory Support: New Data, Old Problems. Circulation 116: 461-462 [Full Text]  
• Lietz, K., Long, J. W., Kfoury, A. G., Slaughter, M. S., Silver, M. A., Milano, C. A., Rogers, J. G., Naka, Y., Mancini, D., Miller, L. W. (2007). Outcomes of Left Ventricular Assist Device Implantation as Destination Therapy in the Post-REMATCH Era: Implications for Patient Selection. Circulation 116: 497-505 [Abstract] [Full Text]  
• Kondoh, H., Sawa, Y., Fukushima, N., Matsumiya, G., Miyagawa, S., Kitagawa-Sakakida, S., Imanishi, Y., Kawaguchi, N., Matsuura, N., Matsuda, H. (2007). Combined Strategy Using Myoblasts and Hepatocyte Growth Factor in Dilated Cardiomyopathic Hamsters. Ann. Thorac. Surg. 84: 134-141 [Abstract] [Full Text]  
• Patel, J., Heywood, J. T. (2007). Mode of Death in Patients With Systolic Heart Failure. J CARDIOVASC PHARMACOL THER 12: 127-136 [Abstract]  
• Patel, N. D., Williams, J. A., Nwakanma, L. U., Weiss, E. S., Conte, J. V. (2007). Impact of Lateral Wall Myocardial Infarction on Outcomes After Surgical Ventricular Restoration. Ann. Thorac. Surg. 83: 2017-2028 [Abstract] [Full Text]  
• Slaughter, M. S., Tsui, S. S., El-Banayosy, A., Sun, B. C., Kormos, R. L., Mueller, D. K., Massey, H. T., Icenogle, T. B., Farrar, D. J., Hill, J. D., IVAD Study Group, (2007). Results of a multicenter clinical trial with the Thoratec Implantable Ventricular Assist Device. J. Thorac. Cardiovasc. Surg. 133: 1573-1580 [Abstract] [Full Text]  
• Asai, T., Lee, M.-H., Arrecubieta, C., von Bayern, M. P., Cespedes, C. A., Baron, H. M., Cadeiras, M., Sakaguchi, T., Marboe, C. C., Naka, Y., Deng, M. C., Lowy, F. D. (2007). Cellular coating of the left ventricular assist device textured polyurethane membrane reduces adhesion of Staphylococcus aureus. J. Thorac. Cardiovasc. Surg. 133: 1147-1153 [Abstract] [Full Text]  
• Friedrich, E. B, Bohm, M. (2007). MANAGEMENT OF END STAGE HEART FAILURE. Heart 93: 626-631 [Full Text]  
• Sartipy, U., Albage, A., Lindblom, D. (2007). Improved Health-Related Quality of Life and Functional Status After Surgical Ventricular Restoration. Ann. Thorac. Surg. 83: 1381-1387 [Abstract] [Full Text]  
• Jugdutt, B. I., Butler, C. (2007). Ventricular Unloading, Tissue Angiotensin II, Matrix Modulation, and Function During Left Ventricular Assist Device Support. J Am Coll Cardiol 49: 1175-1177 [Full Text]  
• Zimpfer, D., Zrunek, P., Roethy, W., Czerny, M., Schima, H., Huber, L., Grimm, M., Rajek, A., Wolner, E., Wieselthaler, G. (2007). Left ventricular assist devices decrease fixed pulmonary hypertension in cardiac transplant candidates. J. Thorac. Cardiovasc. Surg. 133: 689-695 [Abstract] [Full Text]  
• Feller, E. D., Sorensen, E. N., Haddad, M., Pierson, R. N., Johnson, F. L., Brown, J. M., Griffith, B. P. (2007). Clinical Outcomes Are Similar in Pulsatile and Nonpulsatile Left Ventricular Assist Device Recipients. Ann. Thorac. Surg. 83: 1082-1088 [Abstract] [Full Text]  
• TERRACCIANO, C. M. N., KOBAN, M. U., SOPPA, G. K., SIEDLECKA, U., LEE, J., STAGG, M. A., YACOUB, M. H. (2007). The Role of the Cardiac Na+/Ca2+ Exchanger in Reverse Remodeling: Relevance for LVAD-Recovery. Ann. N. Y. Acad. Sci. 1099: 349-360 [Abstract] [Full Text]  
• Hall, J. L., Birks, E. J., Grindle, S., Cullen, M. E., Barton, P. J., Rider, J. E., Lee, S., Harwalker, S., Mariash, A., Adhikari, N., Charles, N. J., Felkin, L. E., Polster, S., George, R. S., Miller, L. W., Yacoub, M. H. (2007). Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapy. Eur Heart J 28: 613-627 [Abstract] [Full Text]  
• Large, S. (2007). Surgery for heart failure. Heart 93: 392-402 [Full Text]  
• Travis, A. R., Giridharan, G. A., Pantalos, G. M., Dowling, R. D., Prabhu, S. D., Slaughter, M. S., Sobieski, M., Undar, A., Farrar, D. J., Koenig, S. C. (2007). Vascular pulsatility in patients with a pulsatile- or continuous-flow ventricular assist device. J. Thorac. Cardiovasc. Surg. 133: 517-524 [Abstract] [Full Text]  
• Wohlschlaeger, J., Schmitz, K. J., Palatty, J., Takeda, A., Takeda, N., Vahlhaus, C., Levkau, B., Stypmann, J., Schmid, C., Schmid, K. W., Baba, H. A. (2007). Roles of cyclooxygenase-2 and phosphorylated Akt ( T hr308) in cardiac hypertrophy regression mediated by left-ventricular unloading. J. Thorac. Cardiovasc. Surg. 133: 37-43 [Abstract] [Full Text]  
• Large, S. (2007). Invited commentary. Ann. Thorac. Surg. 83: 282-282 [Full Text]  
• Nanas, J. N., Matsouka, C., Karageorgopoulos, D., Leonti, A., Tsolakis, E., Drakos, S. G., Tsagalou, E. P., Maroulidis, G. D., Alexopoulos, G. P., Kanakakis, J. E., Anastasiou-Nana, M. I. (2006). Etiology of Anemia in Patients With Advanced Heart Failure. J Am Coll Cardiol 48: 2485-2489 [Abstract] [Full Text]  
• Clegg, A. J., Scott, D. A., Loveman, E., Colquitt, J. L., Royle, P., Bryant, J. (2006). Clinical and cost-effectiveness of left ventricular assist devices as a bridge to heart transplantation for people with end-stage heart failure: a systematic review and economic evaluation. Eur Heart J 27: 2929-2938 [Abstract] [Full Text]  
• Bugger, H., Leippert, S., Blum, D., Kahle, P., Barleon, B., Marme, D., Doenst, T. (2006). Subtractive hybridization for differential gene expression in mechanically unloaded rat heart. Am. J. Physiol. Heart Circ. Physiol. 291: H2714-H2722 [Abstract] [Full Text]  
• Skali, H., Pfeffer, M. A., Lubsen, J., Solomon, S. D. (2006). Variable Impact of Combining Fatal and Nonfatal End Points in Heart Failure Trials. Circulation 114: 2298-2303 [Abstract] [Full Text]  
• Russo, M. J., Chen, J. M., Hong, K. N., Stewart, A. S., Ascheim, D. D., Argenziano, M., Mancini, D. M., Oz, M. C., Naka, Y., the Columbia University Heart Transplant Outcomes, (2006). Survival After Heart Transplantation Is Not Diminished Among Recipients With Uncomplicated Diabetes Mellitus: An Analysis of the United Network of Organ Sharing Database. Circulation 114: 2280-2287 [Abstract] [Full Text]  
• Birks, E. J., Tansley, P. D., Hardy, J., George, R. S., Bowles, C. T., Burke, M., Banner, N. R., Khaghani, A., Yacoub, M. H. (2006). Left Ventricular Assist Device and Drug Therapy for the Reversal of Heart Failure. NEJM 355: 1873-1884 [Abstract] [Full Text]  
• Renlund, D. G., Kfoury, A. G. (2006). When the Failing, End-Stage Heart Is Not End-Stage. NEJM 355: 1922-1925 [Full Text]  
• Christiansen, S., Autschbach, R. (2006). Doxorubicin in experimental and clinical heart failure.. Eur. J. Cardiothorac. Surg. 30: 611-616 [Abstract] [Full Text]  
• Pagani, F. D., Long, J. W., Dembitsky, W. P., Joyce, L. D., Miller, L. W. (2006). Improved Mechanical Reliability of the HeartMate XVE Left Ventricular Assist System.. Ann. Thorac. Surg. 82: 1413-1418 [Abstract] [Full Text]  
• LANDESBERG, A., SHENHAV, A., SHOFTY, R., KONYUKHOV, E., LEVY, C., LICHTENSTEIN, O., BEYAR, R., TER KEURS, H. E.D.J, LANDESBERG, G., CABRERA, M., STANLEY, W., SAIDEL, G. M (2006). Effects of Synchronized Cardiac Assist Device on Cardiac Energetics. Ann. N. Y. Acad. Sci. 1080: 466-478 [Abstract] [Full Text]  
• Toyama, M., Usui, A., Abe, T., Oshima, H., Akita, T., Ueda, Y. (2006). Mitral Valve Surgery for Dilated Cardiomyopathy with Mitral Regurgitation. Asian Cardiovasc. Thorac. Ann. 14: 371-376 [Abstract] [Full Text]  
• Shah, K. B., Inoue, Y., Mehra, M. R. (2006). Amyloidosis and the heart: a comprehensive review.. Arch Intern Med 166: 1805-1813 [Abstract] [Full Text]  
• Chen, E., Sapirstein, W., Ahn, C., Swain, J., Zuckerman, B. (2006). FDA perspective on clinical trial design for cardiovascular devices.. Ann. Thorac. Surg. 82: 773-775 [Full Text]  
• Cohn, L. H. (2006). Evidence-based cardiac surgery. J. Thorac. Cardiovasc. Surg. 132: 457-458 [Full Text]  
• Dembitsky, W. P. (2006). REMATCH and Beyond: The Cost of Treating Heart Failure Using an Implantable Left Ventricular Assist Device.. SEMIN CARDIOTHORAC VASC ANESTH 10: 253-255 [Abstract]  
• Parides, M. K., Moskowitz, A. J., Ascheim, D. D., Rose, E. A., Gelijns, A. C. (2006). Progress versus precision: challenges in clinical trial design for left ventricular assist devices.. Ann. Thorac. Surg. 82: 1140-1146 [Abstract] [Full Text]  
• Crespo-Leiro, M. G., Cuenca-Castillo, J. J. (2006). Surgical treatment of heart failure: heart transplantation and ventricular restoration surgery. Eur Heart J Suppl 8: E39-E42 [Abstract] [Full Text]  
• Santambrogio, L., Bianchi, T., Fuardo, M., Gazzoli, F., Veronesi, R., Braschi, A., Maurelli, M. (2006). Right ventricular failure after left ventricular assist device insertion: preoperative risk factors. ICVTS 5: 379-382 [Abstract] [Full Text]  
• Westaby, S., Frazier, O.H., Banning, A. (2006). Six years of continuous mechanical circulatory support.. NEJM 355: 325-327 [Full Text]  
• Lima, B., Rajagopal, K., Petersen, R. P., Shah, A. S., Soule, B., Felker, G. M., Rogers, J. G., Lodge, A. J., Milano, C. A. (2006). Marginal Cardiac Allografts Do Not Have Increased Primary Graft Dysfunction in Alternate List Transplantation. Circulation 114: I-27-I-32 [Abstract] [Full Text]  
• Blume, E. D., Naftel, D. C., Bastardi, H. J., Duncan, B. W., Kirklin, J. K., Webber, S. A., for the Pediatric Heart Transplant Study Investiga, (2006). Outcomes of Children Bridged to Heart Transplantation With Ventricular Assist Devices: A Multi-Institutional Study. Circulation 113: 2313-2319 [Abstract] [Full Text]  
• Petrucci, R. J., Truesdell, K. C., Carter, A., Goldstein, N. E., Russell, M. M., Dilkes, D., Fitzpatrick, J. M., Thomas, C. E., Keenan, M. E., Lazarus, L. A., Chiaravalloti, N. D., Trunzo, J. J., Verjans, J. W., Holmes, E. C., Samuels, L. E., Narula, J. (2006). Cognitive dysfunction in advanced heart failure and prospective cardiac assist device patients.. Ann. Thorac. Surg. 81: 1738-1744 [Abstract] [Full Text]  
• Siegenthaler, M. P., Frazier, O.H., Beyersdorf, F., Martin, J., Laks, H., Elefteriades, J., Khaghani, A., Kjellman, U., Koul, B., Pepper, J., Jarvik, R., Westaby, S. (2006). Mechanical reliability of the jarvik 2000 heart.. Ann. Thorac. Surg. 81: 1752-1759 [Abstract] [Full Text]  
• Stevenson, L. W., Lewis, E. (2006). Mapping the Journey. J Am Coll Cardiol 47: 1612-1614 [Full Text]  
• Williams, J., Conte, J. (2006). Ventricular assist device placement following surgical ventricular restoration. ICVTS 5: 90-91 [Abstract] [Full Text]  
• Felker, G. M., Rogers, J. G. (2006). Same Bridge, New Destinations: Rethinking Paradigms for Mechanical Cardiac Support in Heart Failure. J Am Coll Cardiol 47: 930-932 [Abstract] [Full Text]  
• Hauptman, P. J. (2006). Palliation in heart failure: When less and more are more. AM J HOSP PALLIAT CARE 23: 150-152  
• Padalino, M. A., Ohye, R. G., Chang, A. C., Gajarski, R. J., Bove, E. L., Devaney, E. J. (2006). Bridge to Transplant Using the MicroMed DeBakey Ventricular Assist Device in a Child with Idiopathic Dilated Cardiomyopathy.. Ann. Thorac. Surg. 81: 1118-1121 [Abstract] [Full Text]  
• Stevenson, L. W., Le Jemtel, T. H., Alt, E. U., Stevenson, L. W., Le Jemtel, T. H., Alt, E. U. (2006). Hemodynamic Goals Are Relevant. Circulation 113: 1020-1033 [Full Text]  
• Pennington, D. G. (2006). The Impact of New Technology on Cardiothoracic Surgical Practice. Ann. Thorac. Surg. 81: 10-18 [Full Text]  
• Aranda, J. M. Jr, Woo, G. W., Schofield, R. S., Handberg, E. M., Hill, J. A., Curtis, A. B., Sears, S. F., Goff, J. S., Pauly, D. F., Conti, J. B. (2005). Management of Heart Failure After Cardiac Resynchronization Therapy: Integrating Advanced Heart Failure Treatment With Optimal Device Function. J Am Coll Cardiol 46: 2193-2198 [Abstract] [Full Text]  
• Zhang, J., Heitjan, D. F (2005). Nonignorable censoring in randomized clinical trials. Clin Trials 2: 488-496 [Abstract]  
• Potapov, E. V., Weng, Y., Drews, T., Jurmann, M., Hetzer, R. (2005). Longest Time of Support by the Novacor Left Ventricular Assist Device Without Pump Exchange. Ann. Thorac. Surg. 80: 2421-2421 [Full Text]  
• Wohlschlaeger, J., Schmitz, K. J., Schmid, C., Schmid, K. W., Keul, P., Takeda, A., Weis, S., Levkau, B., Baba, H. A. (2005). Reverse remodeling following insertion of left ventricular assist devices (LVAD): A review of the morphological and molecular changes. Cardiovasc Res 68: 376-386 [Abstract] [Full Text]  
• Konstam, M. A., Czerska, B., Bohm, M., Oren, R. M., Sadowski, J., Khanal, S., Abraham, W. T., Wasler, A., Dahm, J. B., Gavazzi, A., Gradinac, S., Legrand, V., Mohacsi, P., Poelzl, G., Radovancevic, B., Van Bakel, A. B., Zile, M. R., Cabuay, B., Bartus, K., Jansen, P. (2005). Continuous Aortic Flow Augmentation: A Pilot Study of Hemodynamic and Renal Responses to a Novel Percutaneous Intervention in Decompensated Heart Failure. Circulation 112: 3107-3114 [Abstract] [Full Text]  
• Ootaki, Y., Kamohara, K., Akiyama, M., Zahr, F., Kopcak, M. W. Jr., Dessoffy, R., Fukamachi, K. (2005). Phasic coronary blood flow pattern during a continuous flow left ventricular assist support. Eur. J. Cardiothorac. Surg. 28: 711-716 [Abstract] [Full Text]  
• Dang, N. C., Topkara, V. K., Kim, B. T., Mercando, M. L., Kay, J., Naka, Y. (2005). Clinical outcomes in patients with chronic congestive heart failure who undergo left ventricular assist device implantation. J. Thorac. Cardiovasc. Surg. 130: 1302-1309 [Abstract] [Full Text]  
• The ESCAPE Investigators and ESCAPE Study Coordina, (2005). Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness: The ESCAPE Trial. JAMA 294: 1625-1633 [Abstract] [Full Text]  
• Yuh, D. D., Albaugh, M., Ullrich, S., Conte, J. V. (2005). Treatment of Ventricular Assist Device Driveline Infection With Vacuum-Assisted Closure System. Ann. Thorac. Surg. 80: 1493-1495 [Abstract] [Full Text]  
• Wilhelm, M. J., Hammel, D., Schmid, C., Rhode, A., Kaan, T., Rothenburger, M., Stypmann, J., Schafers, M., Schmidt, C., Baba, H. A., Scheld, H. H. (2005). Long-term support of 9 patients with the DeBakey VAD for more than 200 days. J. Thorac. Cardiovasc. Surg. 130: 1122-1129 [Abstract] [Full Text]  
• El-Magharbel, I. (2005). Ventricular Assist Devices and Anesthesia. SEMIN CARDIOTHORAC VASC ANESTH 9: 241-249 [Abstract]  
• McCarthy, P. M., Lamm, R. D., Sade, R. M. (2005). Medical Ethics Collides With Public Policy: LVAD for a Patient With Leukemia. Ann. Thorac. Surg. 80: 793-798 [Full Text]  
• Shirakawa, Y., Sawa, Y., Takewa, Y., Tatsumi, E., Kaneda, Y., Taenaka, Y., Matsuda, H. (2005). Gene transfection with human hepatocyte growth factor complementary DNA plasmids attenuates cardiac remodeling after acute myocardial infarction in goat hearts implanted with ventricular assist devices. J. Thorac. Cardiovasc. Surg. 130: 624-632 [Abstract] [Full Text]  
• Dang, N. C., Topkara, V. K., Leacche, M., John, R., Byrne, J. G., Naka, Y. (2005). Left ventricular assist device implantation after acute anterior wall myocardial infarction and cardiogenic shock: A two-center study. J. Thorac. Cardiovasc. Surg. 130: 693-698 [Abstract] [Full Text]  
• Choong, C. K., Pasque, M. K., Shelton, K., Kehoe-Huck, B., Ewald, G. A., Horstmanshof, D., Moazami, N. (2005). The beneficial role of left ventricular assist device destination therapy in the reversal of contraindications to cardiac transplantation. J. Thorac. Cardiovasc. Surg. 130: 879-880 [Full Text]  
• Stevenson, L. W., Shekar, P. (2005). Ventricular Assist Devices for Durable Support. Circulation 112: e111-e115 [Full Text]