In this issue of the Journal, in 't Veld and colleagues1 reportthe results of a long-term prospective study of the relationbetween the use of nonsteroidal antiinflammatory drugs (NSAIDs)and the onset of Alzheimer's disease. This important articleappears to resolve puzzling conflicts among the results of priorstudies of the possible neuroprotective effects of NSAIDs.
The dementia of Alzheimer's disease has an insidious onset anda gradually progressive course. Although the pathogenesis ofthe disease remains controversial, the process is widely thoughtto begin in midlife or earlier, decades before the appearanceof symptoms. At that point, largely . . . [Full Text of this Article]
References
This article has been cited by other articles:
Szekely, C. A., Green, R. C., Breitner, J.C.S., Ostbye, T., Beiser, A. S., Corrada, M. M., Dodge, H. H., Ganguli, M., Kawas, C. H., Kuller, L. H., Psaty, B. M., Resnick, S. M., Wolf, P. A., Zonderman, A. B., Welsh-Bohmer, K. A., Zandi, P. P.
(2008). No advantage of A{beta}42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies. Neurology
70: 2291-2298
[Abstract][Full Text]
Scharf, J. M., Daffner, K. R.
(2007). NSAIDs in the prevention of dementia: A Cache-22?. Neurology
69: 235-236
[Full Text]
Finch, C. E.
(2006). A perspective on sporadic inclusion-body myositis: The role of aging and inflammatory processes. Neurology
66: S1-S6
[Abstract][Full Text]
Etminan, M., Gill, S., Samii, A.
(2003). Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. BMJ
327: 128-
[Abstract][Full Text]
Suthers, K., Kim, J. K., Crimmins, E.
(2003). Life Expectancy With Cognitive Impairment in the Older Population of the United States. Journals of Gerontology Series B: Psychological Sciences and Social Science
58: S179-186
[Abstract][Full Text]
Lippman, S. M., Hong, W. K.
(2002). Cancer Prevention Science and Practice. Cancer Res.
62: 5119-5125
[Full Text]