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Correspondence
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Volume 345:1644-1645 November 29, 2001 Number 22
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Sepsis in a Newborn Due to Pseudomonas aeruginosa from a Contaminated Tub Bath

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To the Editor: Vochem et al. (Aug. 2 issue)1 describe a neonate with disseminated Pseudomonas aeruginosa infection that was associated with a contaminated tub bath. Of concern is the description of ampicillin, cefotaxime, and gentamicin as "antipseudomonal chemotherapy" and their use after the isolation of P. aeruginosa from the patient's blood and cerebrospinal fluid.

Although this regimen may not have influenced the outcome in this case, neither ampicillin nor cefotaxime has substantial activity against P. aeruginosa. Gentamicin is characterized by enhanced penetration across the blood–brain barrier in neonates, but it also may not reach bactericidal levels in the cerebrospinal . . . [Full Text of this Article]

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