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Previous Volume 345:1706-1707 December 6, 2001 Number 23 Next

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To the Editor: Modan and colleagues (July 26 issue)¹ conclude that oral contraceptives do not protect against ovarian cancer in Israeli Jewish women carrying BRCA mutations. We have shown, in two studies of Jewish and non-Jewish women with BRCA mutations, that the use of oral contraceptives was strongly protective against ovarian cancer.^2,3 In our recent study, the odds ratio for ovarian cancer among women who had used oral contraceptives was 0.44 (95 percent confidence interval, 0.28 to 0.68).³

Relevant differences may exist between Jews and non-Jews, between carriers of the three founder mutations common among Jews and carriers of other . . . [Full Text of this Article]

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