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Correspondence
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Volume 345:1711-1712 December 6, 2001 Number 23
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Nephrectomy and Interleukin-2 for Metastatic Renal-Cell Carcinoma

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 by Tannock, I. F.
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To the Editor: In this issue of the Journal, Flanigan et al.1 report the results of a randomized trial conducted by the Southwest Oncology Group (SWOG), which compared interferon alone with nephrectomy followed by interferon for the treatment of metastatic renal-cell cancer. There was a survival advantage in the surgery-plus-interferon group, as well as in all the risk strata. Similar results have been demonstrated in Europe by the Genito-Urinary Group of the European Organisation for Research and Treatment of Cancer, in a study with a similar protocol.2 However, the issue of the most effective immunotherapeutic agent to use after nephrectomy . . . [Full Text of this Article]

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