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Previous Volume 345:1776-1777 December 13, 2001 Number 24 Next

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To the Editor: In the August 9 issue, Faust et al.¹ reported that the level of endothelial expression of thrombomodulin and the endothelial protein C receptor was lower in patients with meningococcal sepsis than in control subjects. This finding has clinical implications, because it suggests that therapy with activated protein C² may be superior to treatment with unactivated protein C³ in patients with sepsis. The conclusions of Faust et al. were based in part on immunohistochemical studies of skin-biopsy specimens. One potential pitfall of this type of analysis is that, depending on the timing of the biopsies and the location . . . [Full Text of this Article]

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