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Previous Volume 345:1850-1852 December 20, 2001 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Lieberman et al. (Aug. 23 issue)¹ report that one-time screening with both a fecal occult-blood test and sigmoidoscopy failed to identify 24 percent of subjects with advanced neoplasia. They do not, however, comment on the incremental risk of death from colorectal cancer that this rate of missed diagnoses confers on persons with an average risk.

Advanced colonic neoplasms consist of a range of lesions (from large tubular adenomas to early adenocarcinoma) that vary widely in terms of the risk of progression to fatal cancer. The authors do not present separate sensitivity analyses for each of these types . . . [Full Text of this Article]

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