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Correspondence
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Volume 345:1852-1853 December 20, 2001 Number 25
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Anticoagulation for Idiopathic Deep-Vein Thrombosis

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To the Editor: Agnelli et al. (July 19 issue)1 report the results of one of the few large trials addressing the optimal duration of anticoagulant therapy after a first episode of idiopathic deep-vein thrombosis. They state that improving risk stratification among patients with deep-vein thrombosis is a major concern.

Markers of the activation of coagulation may be of value. Besides prothrombin fragment F1+2, the thrombin–antithrombin complex, plasminogen-activator inhibitor type 1, and tissue-plasminogen-activator antigen, d-dimer may be a good candidate. It is a specific clot-lysis product with a high negative predictive value for ruling out acute thromboembolic venous disease.2 The predictive . . . [Full Text of this Article]

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