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Previous Volume 345:1890-1900 December 27, 2001 Number 26 Next

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Since the subject was last reviewed in the Journal,¹ there have been important advances in the treatment of locally advanced head and neck squamous-cell carcinoma. These new approaches incorporate chemotherapy into initial curative treatment to achieve organ preservation and to improve survival. Moreover, progress in the elucidation of the molecular genetic changes that lead to the development of these tumors should soon bring novel diagnostic and therapeutic procedures into clinical practice. This review will highlight these important advances in the treatment of patients with head and neck cancer (Table 1) and emphasize the ways in which molecular biology . . . [Full Text of this Article]

Molecular Progression of Head and Neck Cancer

Molecular Epidemiology

Diagnosis

Staging

Surgical Innovation

Larynx

Neck Dissection

Reconstruction

Radiotherapy

Altered Fractionation

Radiation Sensitizers

Postoperative Radiotherapy

Repeated Irradiation

Treatment of Patients with Recurrent and Metastatic Disease

Novel Therapies

Combination Therapy

Cancers of the Larynx and Hypopharynx

Cancer of the Oropharynx

Locally Advanced, Unresectable Disease

Nasopharyngeal Carcinoma

Postoperative Adjuvant Chemotherapy

Toxicity of Chemotherapy

Summary

Source Information

From the Department of Otolaryngology–Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore.

Address reprint requests to Dr. Sidransky at the Department of Otolaryngology–Head and Neck Surgery, Johns Hopkins University School of Medicine, 818 Ross Research Bldg., 720 Rutland Ave., Baltimore, MD 21205-2196, or at dsidrans@jhmi.edu.

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