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Previous Volume 345:1913-1914 December 27, 2001 Number 26 Next

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To the Editor: The article by Alldredge et al. (Aug. 30 issue)¹ describes a randomized, controlled study of the prehospital use of benzodiazepines for patients with status epilepticus. I am concerned by the inclusion of a placebo group and by the approval of this study by the institutional review boards. Did this study really provide clinical equipoise? Assuming that the paramedics and physicians are appropriately trained, would the authors or members of the institutional review boards wish to have benzodiazepines withheld in the prehospital setting if they were in status epilepticus?

Robert K. Knopp, M.D.
Regions Hospital
St. Paul, MN . . . [Full Text of this Article]

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