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Previous Volume 345:425-432 August 9, 2001 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Leukoencephalopathy is a structural alteration of cerebral white matter in which myelin suffers the most damage. Toxic leukoencephalopathy may be caused by exposure to a wide variety of agents, including cranial irradiation, therapeutic agents, drugs of abuse, and environmental toxins.¹ Toxic leukoencephalopathy particularly involves white-matter tracts devoted to higher cerebral function, causing clinical features that range from inattention, forgetfulness, and changes in personality to dementia, coma, and death. This review focuses on white-matter damage caused by toxins as distinguished from that caused by disorders such as multiple sclerosis, cerebrovascular disease, and metabolic disturbances.²

Although the prevalence of toxic leukoencephalopathy is . . . [Full Text of this Article]

Clinical Presentation

Diagnosis

White-Matter Toxins

Therapeutic Agents

Drugs of Abuse

Environmental Toxins

Occupational Exposure to Solvents

Prevention and Treatment

Conclusions

Source Information

From the Departments of Neurology (C.M.F., B.K.K.-D.), Pathology, (B.K.K.-D.), and Psychiatry (C.M.F.), University of Colorado School of Medicine, and the Denver Veterans Affairs Medical Center (C.M.F.) — both in Denver.

Address reprint requests to Dr. Filley at the Behavioral Neurology Section, UCHSC B-183, 4200 E. Ninth Ave., Denver, CO 80262, or at christopher.filley@uchsc.edu.

References

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