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Correspondence
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Volume 345:621-622 August 23, 2001 Number 8
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Treatment of Brain Metastases of Malignant Melanoma with Temozolomide

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To the Editor: A 57-year-old man presented with an ulcerative, acral–lentiginous lesion on the sole of the left foot. Pathological examination showed a melanoma (Breslow depth, 2.2 mm; Clark level IV) without involvement of the surgical margins; the dissected ilioinguinal nodes showed micrometastases. A computed tomographic (CT) scan did not show any other lesion. The patient received interferon alfa, but two years later, plantar and ilioinguinal lesions recurred. They were removed twice in five months. Therapy with interferon alfa was stopped.

Two months later, a CT scan showed bilateral metastatic lesions in the lung. The patient was treated with dacarbazine, . . . [Full Text of this Article]

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