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Correspondence
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Volume 345:622-623 August 23, 2001 Number 8
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Acquired Type I von Willebrand's Disease Associated with Highly Substituted Hydroxyethyl Starch

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To the Editor: High-molecular-weight hydroxyethyl starches (hetastarches) can cause acquired type I von Willebrand's disease.1 A case has also occurred after treatment with medium-molecular-weight hydroxyethyl starches (pentastarches).2 We analyzed all patients with hemostatic disorders that occurred during treatment with pentastarch (Elohes and Hesteril, Fresenius, Paris; and Lomol, Dupont, Wilmington, Del.) and that were spontaneously reported to the 31 French regional drug-monitoring centers.

Nine cases of hemostatic disorders were reported between 1990 and 1997 (Table 1). All patients were treated with Elohes as hemodilution therapy (for vasospasm secondary to subarachnoid hemorrhage).

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Table 1. Characteristics of Patients with a Hemostatic Disorder.

 
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