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Previous Volume 345:689-690 August 30, 2001 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Status epilepticus is a series of successive grand mal seizures lasting minutes or even hours, without the recovery of normal consciousness. The resulting metabolic derangement of cells, depletion of the oxygen and glucose necessary for normal functioning, and disruption of ion transport across cell membranes injure neurons and damage the brain.¹ The long-term complications include focal neurologic deficits, epilepsy, and encephalopathy. The longer an episode of status epilepticus lasts, the greater the risk and extent of these serious sequelae.² Although status epilepticus has diverse causes (e.g., medication or alcohol withdrawal, preexisting epilepsy, head injury, stroke, intracranial mass, meningitis, and drug . . . [Full Text of this Article]

References

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• Tisherman, S. A., Powell, J. L., Schmidt, T. A., Aufderheide, T. P., Kudenchuk, P. J., Spence, J., Climer, D., Kelly, D., Marcantonio, A., Brown, T., Sopko, G., Kerber, R., Sugarman, J., Hoyt, D., the Resuscitation Outcomes Consortium Investigator, (2008). Regulatory Challenges for the Resuscitation Outcomes Consortium. Circulation 118: 1585-1592 [Full Text]  
• Knopp, R. K., Su, M., Chodosh, A., Nelson, L. S., Alldredge, B. K., Lowenstein, D. H. (2001). Treatment of Out-of-Hospital Status Epilepticus. NEJM 345: 1913-1914 [Full Text]