Federico Quaini, M.D., Konrad Urbanek, M.D., Antonio P. Beltrami, M.D., Nicoletta Finato, M.D., Carlo A. Beltrami, M.D., Bernardo Nadal-Ginard, M.D., Ph.D., Jan Kajstura, Ph.D., Annarosa Leri, M.D., and Piero Anversa, M.D.
Background Cases in which a male patient receives a heart froma female donor provide an unusual opportunity to test whetherprimitive cells translocate from the recipient to the graftand whether cells with the phenotypic characteristics of thoseof the recipient ultimately reside in the donor heart. The Ychromosome can be used to detect migrated undifferentiated cellsexpressing stem-cell antigens and to discriminate between primitivecells derived from the recipient and those derived from thedonor.
Methods We examined samples from the atria of the recipientand the atria and ventricles of the graft by fluorescence insitu hybridization to determine whether Y chromosomes were presentin eight hearts from female donors implanted into male patients.Primitive cells bearing Y chromosomes that expressed c-kit,MDR1, and Sca-1 were also investigated.
Results Myocytes, coronary arterioles, and capillaries thathad a Y chromosome made up 7 to 10 percent of those in the donorhearts and were highly proliferative. As compared with the ventriclesof control hearts, the ventricles of the transplanted heartshad markedly increased numbers of cells that were positive forc-kit, MDR1, or Sca-1. The number of primitive cells was higherin the atria of the hosts and the atria of the donor heartsthan in the ventricles of the donor hearts, and 12 to 16 percentof these cells contained a Y chromosome. Undifferentiated cellswere negative for markers of bone marrow origin. Progenitorcells expressing MEF2, GATA-4, and nestin (which identify thecells as myocytes) and Flk1 (which identifies the cells as endothelialcells) were identified.
Conclusions Our results show a high level of cardiac chimerismcaused by the migration of primitive cells from the recipientto the grafted heart. Putative stem cells and progenitor cellswere identified in control myocardium and in increased numbersin transplanted hearts.
Source Information
From the Department of Medicine, New York Medical College, Valhalla (F.Q., K.U., A.P.B., B.N.-G., J.K., A.L., P.A.); and the Department of Pathology, University of Udine, Udine, Italy (N.F., C.A.B.).
Address reprint requests to Dr. Anversa at the Department of Medicine, Vosburgh Pavilion, New York Medical College, Valhalla, NY 10595, or at piero_anversa{at}nymc.edu.
D'Alessandro, D. A., Kajstura, J., Hosoda, T., Gatti, A., Bello, R., Mosna, F., Bardelli, S., Zheng, H., D'Amario, D., Padin-Iruegas, M. E., Carvalho, A. B., Rota, M., Zembala, M. O., Stern, D., Rimoldi, O., Urbanek, K., Michler, R. E., Leri, A., Anversa, P.
(2009). Progenitor Cells From the Explanted Heart Generate Immunocompatible Myocardium Within the Transplanted Donor Heart. Circ. Res.
105: 1128-1140
[Abstract][Full Text]
Boudoulas, K. D., Hatzopoulos, A. K.
(2009). Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease. DMM
2: 344-358
[Abstract][Full Text]
Leone, A. M., Valgimigli, M., Giannico, M. B., Zaccone, V., Perfetti, M., D'Amario, D., Rebuzzi, A. G., Crea, F.
(2009). From bone marrow to the arterial wall: the ongoing tale of endothelial progenitor cells. Eur Heart J
30: 890-899
[Abstract][Full Text]
Klabusay, M., Scheer, P., Doubek, M., Rehakova, K., Coupek, P., Horky, D.
(2009). Retention of Nanoparticles-Labeled Bone Marrow Mononuclear Cells in the Isolated Ex Vivo Perfused Heart After Myocardial Infarction in Animal Model. Exp. Biol. Med.
234: 222-231
[Abstract][Full Text]
Suzuki, G., Iyer, V., Cimato, T., Canty, J. M. Jr
(2009). Pravastatin Improves Function in Hibernating Myocardium by Mobilizing CD133+ and cKit+ Bone Marrow Progenitor Cells and Promoting Myocytes to Reenter the Growth Phase of the Cardiac Cell Cycle. Circ. Res.
104: 255-264
[Abstract][Full Text]
Valgimigli, M., Biondi-Zoccai, G. G.L., Malagutti, P., Leone, A. M., Abbate, A.
(2008). Autologous bone marrow stem cell mobilization induced by granulocyte colony-stimulating factor after myocardial infarction. Eur Heart J Suppl
10: K27-K34
[Abstract][Full Text]
Gnecchi, M., Zhang, Z., Ni, A., Dzau, V. J.
(2008). Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy. Circ. Res.
103: 1204-1219
[Abstract][Full Text]
Reinecke, H., Minami, E., Zhu, W.-Z., Laflamme, M. A.
(2008). Cardiogenic Differentiation and Transdifferentiation of Progenitor Cells. Circ. Res.
103: 1058-1071
[Abstract][Full Text]
Amir, G., Ma, X., Reddy, V. M., Hanley, F. L., Reinhartz, O., Ramamoorthy, C., Riemer, R. K.
(2008). Dynamics of Human Myocardial Progenitor Cell Populations in the Neonatal Period. Ann. Thorac. Surg.
86: 1311-1319
[Abstract][Full Text]
Kubo, H., Jaleel, N., Kumarapeli, A., Berretta, R. M., Bratinov, G., Shan, X., Wang, H., Houser, S. R., Margulies, K. B.
(2008). Increased Cardiac Myocyte Progenitors in Failing Human Hearts. Circulation
118: 649-657
[Abstract][Full Text]
Rupp, S., Koyanagi, M., Iwasaki, M., Bauer, J., von Gerlach, S., Schranz, D., Zeiher, A. M., Dimmeler, S.
(2008). Characterization of long-term endogenous cardiac repair in children after heart transplantation. Eur Heart J
29: 1867-1872
[Abstract][Full Text]
Penn, M. S., Mangi, A. A.
(2008). Genetic Enhancement of Stem Cell Engraftment, Survival, and Efficacy. Circ. Res.
102: 1471-1482
[Abstract][Full Text]
Povsic, T. J., Goldschmidt-Clermont, P. J.
(2008). Review: Endothelial progenitor cells: markers of vascular reparative capacity. Ther Adv Cardiovasc Dis
2: 199-213
[Abstract]
Ince, H, Valgimigli, M, Petzsch, M, de Lezo, J S., Kuethe, F, Dunkelmann, S, Biondi-Zoccai, G, Nienaber, C A
(2008). Cardiovascular events and re-stenosis following administration of G-CSF in acute myocardial infarction: systematic review and meta-analysis. Heart
94: 610-616
[Abstract][Full Text]
Orlandi, A., Pagani, F., Avitabile, D., Bonanno, G., Scambia, G., Vigna, E., Grassi, F., Eusebi, F., Fucile, S., Pesce, M., Capogrossi, M. C.
(2008). Functional properties of cells obtained from human cord blood CD34+ stem cells and mouse cardiac myocytes in coculture. Am. J. Physiol. Heart Circ. Physiol.
294: H1541-H1549
[Abstract][Full Text]
Padera, R. F. Jr., Schoen, F. J.
(2008). Pathology of Cardiac Surgery. Card Surg Adult
3: 111-178
[Full Text]
Griffith, B. P., Haddad, M., Poston, R. S.
(2008). Immunobiology of Heart and Heart-Lung Transplantation. Card Surg Adult
3: 1513-1538
[Full Text]
Gallegos, R. P., Bolman, R. M. III
(2008). Stem Cell Induced Regeneration of Myocardium. Card Surg Adult
3: 1657-1668
[Full Text]
Wojakowski, W, Kucia, M, Kazmierski, M, Ratajczak, M Z, Tendera, M
(2008). Circulating progenitor cells in stable coronary heart disease and acute coronary syndromes: relevant reparatory mechanism?. Heart
94: 27-33
[Abstract][Full Text]
Lutz, M., Rosenberg, M., Kiessling, F., Eckstein, V., Heger, T., Krebs, J., Ho, A. D., Katus, H. A., Frey, N.
(2008). Local injection of stem cell factor (SCF) improves myocardial homing of systemically delivered c-kit + bone marrow-derived stem cells. Cardiovasc Res
77: 143-150
[Abstract][Full Text]
Muller, P., Kazakov, A., Semenov, A., Bohm, M., Laufs, U.
(2008). Pressure-induced cardiac overload induces upregulation of endothelial and myocardial progenitor cells. Cardiovasc Res
77: 151-159
[Abstract][Full Text]
Wang, B., Scott, R. C., Pattillo, C. B., Prabhakarpandian, B., Sundaram, S., Kiani, M. F.
(2007). Microvascular transport model predicts oxygenation changes in the infarcted heart after treatment. Am. J. Physiol. Heart Circ. Physiol.
293: H3732-H3739
[Abstract][Full Text]
Bearzi, C., Rota, M., Hosoda, T., Tillmanns, J., Nascimbene, A., De Angelis, A., Yasuzawa-Amano, S., Trofimova, I., Siggins, R. W., LeCapitaine, N., Cascapera, S., Beltrami, A. P., D'Alessandro, D. A., Zias, E., Quaini, F., Urbanek, K., Michler, R. E., Bolli, R., Kajstura, J., Leri, A., Anversa, P.
(2007). Human cardiac stem cells. Proc. Natl. Acad. Sci. USA
104: 14068-14073
[Abstract][Full Text]
Sipido, K. R., Janssens, S. P.
(2007). How Old Is Your Heart?. Circ. Res.
101: 323-325
[Full Text]
Chang, K.-H., Chan-Ling, T., McFarland, E. L., Afzal, A., Pan, H., Baxter, L. C., Shaw, L. C., Caballero, S., Sengupta, N., Calzi, S. L., Sullivan, S. M., Grant, M. B.
(2007). IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development. Proc. Natl. Acad. Sci. USA
104: 10595-10600
[Abstract][Full Text]
Mitchell, R. N., Libby, P.
(2007). Vascular Remodeling in Transplant Vasculopathy. Circ. Res.
100: 967-978
[Abstract][Full Text]
Raisky, O., Nykanen, A. I., Krebs, R., Hollmen, M., Keranen, M. A.I., Tikkanen, J. M., Sihvola, R., Alhonen, L., Salven, P., Wu, Y., Hicklin, D. J., Alitalo, K., Koskinen, P. K., Lemstrom, K. B.
(2007). VEGFR-1 and -2 Regulate Inflammation, Myocardial Angiogenesis, and Arteriosclerosis in Chronically Rejecting Cardiac Allografts. Arterioscler. Thromb. Vasc. Bio.
27: 819-825
[Abstract][Full Text]
Vandervelde, S., van Luyn, M. J.A., Rozenbaum, M. H., Petersen, A. H., Tio, R. A., Harmsen, M. C.
(2007). Stem cell-related cardiac gene expression early after murine myocardial infarction. Cardiovasc Res
73: 783-793
[Abstract][Full Text]
Smith, R. R., Barile, L., Cho, H. C., Leppo, M. K., Hare, J. M., Messina, E., Giacomello, A., Abraham, M. R., Marban, E.
(2007). Regenerative Potential of Cardiosphere-Derived Cells Expanded From Percutaneous Endomyocardial Biopsy Specimens. Circulation
115: 896-908
[Abstract][Full Text]
Gargett, C.E.
(2007). Uterine stem cells: What is the evidence?. Hum Reprod Update
13: 87-101
[Abstract][Full Text]
Schatteman, G. C., Dunnwald, M., Jiao, C.
(2007). Biology of bone marrow-derived endothelial cell precursors. Am. J. Physiol. Heart Circ. Physiol.
292: H1-H18
[Abstract][Full Text]
Hoofnagle, M. H., Thomas, J. A., Wamhoff, B. R., Owens, G. K.
(2006). Origin of Neointimal Smooth Muscle: We've Come Full Circle.. Arterioscler. Thromb. Vasc. Bio.
26: 2579-2581
[Full Text]
Dedja, A., Zaglia, T., Dall'Olmo, L., Chioato, T., Thiene, G., Fabris, L., Ancona, E., Schiaffino, S., Ausoni, S., Cozzi, E.
(2006). Hybrid cardiomyocytes derived by cell fusion in heterotopic cardiac xenografts. FASEB J.
20: 2534-2536
[Abstract][Full Text]
Steinhoff, G., Choi, Y.-H., Stamm, C.
(2006). Intramyocardial bone marrow stem cell treatment for myocardial regeneration. Eur Heart J Suppl
8: H32-H39
[Abstract][Full Text]
Fuster, J. J., Andres, V.
(2006). Telomere Biology and Cardiovascular Disease. Circ. Res.
99: 1167-1180
[Abstract][Full Text]
Forrester, J. S., Shah, P. K., Makkar, R. R.
(2006). Myocardial Regeneration by Stem Cells: Seeing the Unseeable. J Am Coll Cardiol
48: 1722-1724
[Full Text]
Roura, S., Farre, J., Soler-Botija, C., Llach, A., Hove-Madsen, L., Cairo, J. J., Godia, F., Cinca, J., Bayes-Genis, A.
(2006). Effect of aging on the pluripotential capacity of human CD105+ mesenchymal stem cells. Eur J Heart Fail
8: 555-563
[Abstract][Full Text]
Dixon, I. M.C.
(2006). Much ado about bone marrow stem cells: Role in post-myocardial infarct repair. Cardiovasc Res
71: 609-611
[Full Text]
Mollmann, H., Nef, H. M., Kostin, S., von Kalle, C., Pilz, I., Weber, M., Schaper, J., Hamm, C. W., Elsasser, A.
(2006). Bone marrow-derived cells contribute to infarct remodelling. Cardiovasc Res
71: 661-671
[Abstract][Full Text]
Pfeiffer, P., Muller, P., Kazakov, A., Kindermann, I., Bohm, M.
(2006). Time-Dependent Cardiac Chimerism in Gender-Mismatched Heart Transplantation Patients. J Am Coll Cardiol
48: 843-845
[Full Text]
Bottio, T., Vida, V., Padalino, M., Gerosa, G., Stellin, G.
(2006). Early and long-term prognostic value of Troponin-I after cardiac surgery in newborns and children.. Eur. J. Cardiothorac. Surg.
30: 250-255
[Abstract][Full Text]
Brocker, V., Langer, F., Fellous, T. G., Mengel, M., Brittan, M., Bredt, M., Milde, S., Welte, T., Eder, M., Haverich, A., Alison, M. R., Kreipe, H., Lehmann, U.
(2006). Fibroblasts of Recipient Origin Contribute to Bronchiolitis Obliterans in Human Lung Transplants. Am. J. Respir. Crit. Care Med.
173: 1276-1282
[Abstract][Full Text]
Murry, C. E., Reinecke, H., Pabon, L. M.
(2006). Regeneration Gaps: Observations on Stem Cells and Cardiac Repair. J Am Coll Cardiol
47: 1777-1785
[Abstract][Full Text]
Anversa, P., Leri, A., Kajstura, J.
(2006). Cardiac Regeneration. J Am Coll Cardiol
47: 1769-1776
[Abstract][Full Text]
S.M., P., T., M., A., S., H.T., Y., D., C., S.A., K., V.P., S., B., W., P.S., L., S.M., T., K., C., A., S., D., C., A.D., H., H., T., M, O., CAFE Investigators, , Anglo-Scandinavian Cardiac Outcomes Trial Investig, , CAFE Steering Committee and Writing Committee, , D., Z., I., O., J., M., K., S., F., M., T., I., G., M., J., v. W., H., B., M., S., J., D., C., S., M., S., A., K., A., S., REVIVAL-2 Investigators,
(2006). Leaking Capillaries and White Lung in Sepsis--Is Angiopoietin 2 the Culprit?: Excess Circulating Angiopoietin-2 May Contribute to Pulmonary Vascular Leak in Sepsis in Humans. PLoS Medicine 3: e46, 2006. J. Am. Soc. Nephrol.
17: 1207-1217
[Full Text]
Fukuda, K., Yuasa, S.
(2006). Stem Cells as a Source of Regenerative Cardiomyocytes. Circ. Res.
98: 1002-1013
[Abstract][Full Text]
Reinders, M. E.J., Rabelink, T. J., Briscoe, D. M.
(2006). Angiogenesis and Endothelial Cell Repair in Renal Disease and Allograft Rejection. J. Am. Soc. Nephrol.
17: 932-942
[Abstract][Full Text]
Iwakura, A., Shastry, S., Luedemann, C., Hamada, H., Kawamoto, A., Kishore, R., Zhu, Y., Qin, G., Silver, M., Thorne, T., Eaton, L., Masuda, H., Asahara, T., Losordo, D. W.
(2006). Estradiol Enhances Recovery After Myocardial Infarction by Augmenting Incorporation of Bone Marrow-Derived Endothelial Progenitor Cells Into Sites of Ischemia-Induced Neovascularization via Endothelial Nitric Oxide Synthase-Mediated Activation of Matrix Metalloproteinase-9. Circulation
113: 1605-1614
[Abstract][Full Text]
Anversa, P., Kajstura, J., Leri, A., Bolli, R.
(2006). Life and Death of Cardiac Stem Cells: A Paradigm Shift in Cardiac Biology. Circulation
113: 1451-1463
[Full Text]
Seguin, A., Martinod, E., Kambouchner, M., Campo, G. O., Dhote, P., Bruneval, P., Azorin, J. F., Carpentier, A.
(2006). Carinal Replacement With an Aortic Allograft. Ann. Thorac. Surg.
81: 1068-1074
[Abstract][Full Text]
Goette, A., Jentsch-Ullrich, K., Hammwohner, M., Trautmann, S., Franke, A., Klein, H. U., Auricchio, A.
(2006). Cardiac uptake of progenitor cells in patients with moderate-to-severe left ventricular failure scheduled for cardiac resynchronization therapy.. Europace
8: 157-160
[Abstract][Full Text]
Valujskikh, A., Zhang, Q., Heeger, P. S.
(2006). CD8 T Cells Specific for a Donor-Derived, Self-Restricted Transplant Antigen Are Nonpathogenic Bystanders after Vascularized Heart Transplantation in Mice. J. Immunol.
176: 2190-2196
[Abstract][Full Text]
Taneera, J., Rosengren, A., Renstrom, E., Nygren, J. M., Serup, P., Rorsman, P., Jacobsen, S. E. W.
(2006). Failure of Transplanted Bone Marrow Cells to Adopt a Pancreatic {beta}-Cell Fate. Diabetes
55: 290-296
[Abstract][Full Text]
Ruel, M., Suuronen, E. J.
(2006). Invited commentary. Ann. Thorac. Surg.
81: 167-168
[Full Text]
Rao, V.
(2005). Stem cell transplantation for ischemic cardiomyopathy: Hope or hype?. J. Thorac. Cardiovasc. Surg.
130: 1492-1493
[Full Text]
Zimmermann, W.-H., Eschenhagen, T.
(2005). Questioning the relevance of circulating cardiac progenitor cells in cardiac regeneration. Cardiovasc Res
68: 344-346
[Full Text]
Ausoni, S., Zaglia, T., Dedja, A., Di Lisi, R., Seveso, M., Ancona, E., Thiene, G., Cozzi, E., Schiaffino, S.
(2005). Host-derived circulating cells do not significantly contribute to cardiac regeneration in heterotopic rat heart transplants. Cardiovasc Res
68: 394-404
[Abstract][Full Text]
Mouquet, F., Pfister, O., Jain, M., Oikonomopoulos, A., Ngoy, S., Summer, R., Fine, A., Liao, R.
(2005). Restoration of Cardiac Progenitor Cells After Myocardial Infarction by Self-Proliferation and Selective Homing of Bone Marrow-Derived Stem Cells. Circ. Res.
97: 1090-1092
[Abstract][Full Text]
Murry, C. E., Field, L. J., Menasche, P.
(2005). Cell-Based Cardiac Repair: Reflections at the 10-Year Point. Circulation
112: 3174-3183
[Full Text]
Ince, H., Petzsch, M., Kleine, H. D., Schmidt, H., Rehders, T., Korber, T., Schumichen, C., Freund, M., Nienaber, C. A.
(2005). Preservation From Left Ventricular Remodeling by Front-Integrated Revascularization and Stem Cell Liberation in Evolving Acute Myocardial Infarction by Use of Granulocyte-Colony-Stimulating Factor (FIRSTLINE-AMI). Circulation
112: 3097-3106
[Abstract][Full Text]
Minami, E., Laflamme, M. A., Saffitz, J. E., Murry, C. E.
(2005). Extracardiac Progenitor Cells Repopulate Most Major Cell Types in the Transplanted Human Heart. Circulation
112: 2951-2958
[Abstract][Full Text]
Dimarakis, I., Habib, N. A., Gordon, M. Y.A.
(2005). Adult bone marrow-derived stem cells and the injured heart: just the beginning?. Eur. J. Cardiothorac. Surg.
28: 665-676
[Abstract][Full Text]
Memon, I. A., Sawa, Y., Fukushima, N., Matsumiya, G., Miyagawa, S., Taketani, S., Sakakida, S. K., Kondoh, H., Aleshin, A. N., Shimizu, T., Okano, T., Matsuda, H.
(2005). Repair of impaired myocardium by means of implantation of engineered autologous myoblast sheets. J. Thorac. Cardiovasc. Surg.
130: 1333-1341
[Abstract][Full Text]
El-Helou, V., Dupuis, J., Proulx, C., Drapeau, J., Clement, R., Gosselin, H., Villeneuve, L., Manganas, L., Calderone, A.
(2005). Resident Nestin+ Neural-Like Cells and Fibers Are Detected in Normal and Damaged Rat Myocardium. Hypertension
46: 1219-1225
[Abstract][Full Text]
Chimenti, C., Pieroni, M., Russo, A., Sale, P., Russo, M. A., Maseri, A., Frustaci, A.
(2005). Laser Microdissection in Clinical Cardiovascular Research. Chest
128: 2876-2881
[Abstract][Full Text]
Leri, A., Kajstura, J., Anversa, P.
(2005). Cardiac Stem Cells and Mechanisms of Myocardial Regeneration. Physiol. Rev.
85: 1373-1416
[Abstract][Full Text]
Yamani, M. H., Ratliff, N. B., Cook, D. J., Tuzcu, E. M., Yu, Y., Hobbs, R., Rincon, G., Bott-Silverman, C., Young, J. B., Smedira, N., Starling, R. C.
(2005). Peritransplant Ischemic Injury Is Associated With Up-Regulation of Stromal Cell-Derived Factor-1. J Am Coll Cardiol
46: 1029-1035
[Abstract][Full Text]
Valgimigli, M., Rigolin, G. M., Cittanti, C., Malagutti, P., Curello, S., Percoco, G., Bugli, A. M., Porta, M. D., Bragotti, L. Z., Ansani, L., Mauro, E., Lanfranchi, A., Giganti, M., Feggi, L., Castoldi, G., Ferrari, R.
(2005). Use of granulocyte-colony stimulating factor during acute myocardial infarction to enhance bone marrow stem cell mobilization in humans: clinical and angiographic safety profile. Eur Heart J
26: 1838-1845
[Abstract][Full Text]
Bertani, N., Malatesta, P., Volpi, G., Sonego, P., Perris, R.
(2005). Neurogenic potential of human mesenchymal stem cells revisited: analysis by immunostaining, time-lapse video and microarray. J. Cell Sci.
118: 3925-3936
[Abstract][Full Text]
Ince, H., Petzsch, M., Kleine, H. D., Eckard, H., Rehders, T., Burska, D., Kische, S., Freund, M., Nienaber, C. A.
(2005). Prevention of Left Ventricular Remodeling With Granulocyte Colony-Stimulating Factor After Acute Myocardial Infarction: Final 1-year Results of the Front-Integrated Revascularization and Stem Cell Liberation in Evolving Acute Myocardial Infarction by Granulocyte Colony-Stimulating Factor (FIRSTLINE-AMI) Trial. Circulation
112: I-73-I-80
[Abstract][Full Text]
Woo, Y. J., Grand, T. J., Berry, M. F., Atluri, P., Moise, M. A., Hsu, V. M., Cohen, J., Fisher, O., Burdick, J., Taylor, M., Zentko, S., Liao, G., Smith, M., Kolakowski, S., Jayasankar, V., Gardner, T. J., Sweeney, H. L.
(2005). Stromal cell-derived factor and granulocyte-monocyte colony-stimulating factor form a combined neovasculogenic therapy for ischemic cardiomyopathy. J. Thorac. Cardiovasc. Surg.
130: 321-329
[Abstract][Full Text]
Sharma, A. D., Cantz, T., Richter, R., Eckert, K., Henschler, R., Wilkens, L., Jochheim-Richter, A., Arseniev, L., Ott, M.
(2005). Human Cord Blood Stem Cells Generate Human Cytokeratin 18-Negative Hepatocyte-Like Cells in Injured Mouse Liver. Am. J. Pathol.
167: 555-564
[Abstract][Full Text]
Urbanek, K., Torella, D., Sheikh, F., De Angelis, A., Nurzynska, D., Silvestri, F., Beltrami, C. A., Bussani, R., Beltrami, A. P., Quaini, F., Bolli, R., Leri, A., Kajstura, J., Anversa, P.
(2005). Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc. Natl. Acad. Sci. USA
102: 8692-8697
[Abstract][Full Text]
Leone, A. M., Rutella, S., Bonanno, G., Abbate, A., Rebuzzi, A. G., Giovannini, S., Lombardi, M., Galiuto, L., Liuzzo, G., Andreotti, F., Lanza, G. A., Contemi, A. M., Leone, G., Crea, F.
(2005). Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. Eur Heart J
26: 1196-1204
[Abstract][Full Text]
Haider, H. K., Ashraf, M.
(2005). Bone marrow stem cell transplantation for cardiac repair. Am. J. Physiol. Heart Circ. Physiol.
288: H2557-H2567
[Abstract][Full Text]
Hoenig, M. R., Campbell, G. R., Rolfe, B. E., Campbell, J. H.
(2005). Tissue-Engineered Blood Vessels: Alternative to Autologous Grafts?. Arterioscler. Thromb. Vasc. Bio.
25: 1128-1134
[Abstract][Full Text]
Davis, L., Thornburg, K. L., Giraud, G. D.
(2005). The effects of anaemia as a programming agent in the fetal heart. J. Physiol.
565: 35-41
[Abstract][Full Text]
Costa, M. A., Simon, D. I.
(2005). Molecular Basis of Restenosis and Drug-Eluting Stents. Circulation
111: 2257-2273
[Full Text]
Ma, N., Stamm, C., Kaminski, A., Li, W., Kleine, H.-D., Muller-Hilke, B., Zhang, L., Ladilov, Y., Egger, D., Steinhoff, G.
(2005). Human cord blood cells induce angiogenesis following myocardial infarction in NOD/scid-mice. Cardiovasc Res
66: 45-54
[Abstract][Full Text]
Dawn, B., Stein, A. B., Urbanek, K., Rota, M., Whang, B., Rastaldo, R., Torella, D., Tang, X.-L., Rezazadeh, A., Kajstura, J., Leri, A., Hunt, G., Varma, J., Prabhu, S. D., Anversa, P., Bolli, R.
(2005). Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function. Proc. Natl. Acad. Sci. USA
102: 3766-3771
[Abstract][Full Text]
Aractingi, S., Kanitakis, J., Euvrard, S., Le Danff, C., Peguillet, I., Khosrotehrani, K., Lantz, O., Carosella, E. D.
(2005). Skin Carcinoma Arising From Donor Cells in a Kidney Transplant Recipient. Cancer Res.
65: 1755-1760
[Abstract][Full Text]
Schachinger, V., Zeiher, A. M.
(2005). Stem Cells and Cardiovascular and Renal Disease: Today and Tomorrow. J. Am. Soc. Nephrol.
16: S2-S6
[Abstract][Full Text]
Deten, A., Volz, H. C., Clamors, S., Leiblein, S., Briest, W., Marx, G., Zimmer, H.-G.
(2005). Hematopoietic stem cells do not repair the infarcted mouse heart. Cardiovasc Res
65: 52-63
[Abstract][Full Text]
Massa, M., Rosti, V., Ferrario, M., Campanelli, R., Ramajoli, I., Rosso, R., De Ferrari, G. M., Ferlini, M., Goffredo, L., Bertoletti, A., Klersy, C., Pecci, A., Moratti, R., Tavazzi, L.
(2005). Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction. Blood
105: 199-206
[Abstract][Full Text]
Dell'Agnola, C., Wang, Z., Storb, R., Tapscott, S. J., Kuhr, C. S., Hauschka, S. D., Lee, R. S., Sale, G. E., Zellmer, E., Gisburne, S., Bogan, J., Kornegay, J. N., Cooper, B. J., Gooley, T. A., Little, M.-T.
(2004). Hematopoietic stem cell transplantation does not restore dystrophin expression in Duchenne muscular dystrophy dogs. Blood
104: 4311-4318
[Abstract][Full Text]
Berry, M. F., Pirolli, T. J., Jayasankar, V., Morine, K. J., Moise, M. A., Fisher, O., Gardner, T. J., Patterson, P. H., Woo, Y. J.
(2004). Targeted overexpression of leukemia inhibitory factor to preserve myocardium in a rat model of postinfarction heart failure. J. Thorac. Cardiovasc. Surg.
128: 866-875
[Abstract][Full Text]
Mengel, M., Jonigk, D., Wilkens, L., Radermacher, J., von Wasielewski, R., Lehmann, U., Haller, H., Mihatsch, M., Kreipe, H.
(2004). Chimerism of Metanephric Adenoma but Not of Carcinoma in Kidney Transplants. Am. J. Pathol.
165: 2079-2085
[Abstract][Full Text]
Anversa, P., Kajstura, J., Leri, A.
(2004). Circulating Progenitor Cells: Search for an Identity. Circulation
110: 3158-3160
[Full Text]
Borue, X., Lee, S., Grove, J., Herzog, E. L., Harris, R., Diflo, T., Glusac, E., Hyman, K., Theise, N. D., Krause, D. S.
(2004). Bone Marrow-Derived Cells Contribute to Epithelial Engraftment during Wound Healing. Am. J. Pathol.
165: 1767-1772
[Abstract][Full Text]
Fernandez-Aviles, F., San Roman, J. A., Garcia-Frade, J., Fernandez, M. E., Penarrubia, M. J., de la Fuente, L., Gomez-Bueno, M., Cantalapiedra, A., Fernandez, J., Gutierrez, O., Sanchez, P. L., Hernandez, C., Sanz, R., Garcia-Sancho, J., Sanchez, A.
(2004). Experimental and Clinical Regenerative Capability of Human Bone Marrow Cells After Myocardial Infarction. Circ. Res.
95: 742-748
[Abstract][Full Text]
Previous
